Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zrnc, TA; Wallner, J; Zemann, W; Pau, M; Gstettner, C; Brcic, L; Assaf, AT; Hassanzadeh, H; Feichtinger, M; Schwenzer-Zimmerer, K.
Assessment of tumor margins in head and neck cancer using a 3D-navigation system based on PET/CT image-fusion - A pilot study.
J Craniomaxillofac Surg. 2018; 46(4):617-623
Doi: 10.1016/j.jcms.2018.01.011
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zrnc Tomislav
- Co-Autor*innen der Med Uni Graz
- Brcic Luka
- Feichtinger Matthias
- Gstettner Christian
- Pau Mauro
- Schwenzer-Zimmerer Katja Christine
- Wallner Jürgen
- Zemann Wolfgang
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- Abstract:
- Determination of tumor margins in patients with squamous cell carcinoma of the head and neck (SCCHN) is mostly based on preoperative magnetic resonance imaging (MRI) or computed tomography scans (CT). Local recurrence of disease is often correlated with the presence of positive resection margins after surgical treatment. Positron emission tomography/computed tomography (PET/CT) imaging plays a crucial role in the assessment of patients with SCCHN. The purpose of this study was to determine whether PET/CT could predict tumor extension. In 12 patients who underwent surgical treatment of primary SCCHN (Stage III-IV) F18-FDG PET/CT image-fusion was performed on a 3D navigation-system based workstation. Image-guided needle biopsies were obtained from four different, color-coded metabolic areas within the tumor. The histopathological findings were correlated with findings on corresponding PET/CT scans. 81.3% of biopsies from the central area were positive. Specimens taken from the outer metabolic zone were positive in 66.7% of the patients. The highest incidence of positive biopsies was found in the zone adjacent to the outermost area. There was a statistically significant difference in positive tumor histopathology when comparing the various metabolic zones (p = 0.03). Exact determination of tumor is an important research topic, although results remain controversial. The results of this study suggest that in some cases PET scans may overestimate tumor extension. Copyright © 2018. Published by Elsevier Ltd.
- Find related publications in this database (Keywords)
- Squamous cell carcinoma
- PET/CT
- Image guided navigation
- Tumor margins
- Needle biopsy
- Patient outcome