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Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Heitzer, E; Speicher, MR.
Digital Circulating Tumor Cell Analyses for Prostate Cancer Precision Oncology.
Cancer Discov. 2018; 8(3): 269-271. Doi: 10.1158/2159-8290.CD-18-0075 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Heitzer Ellen

Speicher Michael

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Abstract:

In this issue ofCancer Discovery, Miyamoto and colleagues adapted their microfluidic CTC-iChip isolation platform with a digital RNA-PCR readout for eight prostate-specific transcripts and two assays for the androgen receptor mRNA splice variantARV7and theTMPRSS2-ERGtranslocation transcript. In patients with metastatic castrate-resistant prostate cancer at initiating abiraterone therapy in a first-line setting, the resulting RNA-based digital circulating tumor cell signatures identified patients with a shorter overall survival, and in patients with clinically localized disease, the signatures identified those with seminal vesicle invasion and pelvic lymph node involvement.Cancer Discov; 8(3); 269-71. ©2018 AACR.See related article by Miyamoto et al., p. 288. ©2018 American Association for Cancer Research.