Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bhat, VK; Krump, C; Bernhart, E; Becker, JC; Sattler, W; Ghaffari-Tabrizi-Wizsy, N.
A short-term in vivo model for Merkel Cell Carcinoma.
Exp Dermatol. 2018; 27(6):684-687
Doi: 10.1111/exd.13529
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bhat Kumble Vishwanath
- Ghaffari Tabrizi-Wizsy Nassim
- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
- Bernhart Eva Maria
- Krump Corinna
- Sattler Wolfgang
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In vivo tumor models are essential for studying the biology of cancer, identifying tumor targets and evaluating antitumor drugs. Considering the request for the minimisation of animal experiments and following the "3R"-rule ("replacement," "refinement," "reduction"), it has become crucial to develop alternative experimental models in cancer biology. Several studies have already described the avian chorioallantoic membrane (CAM) model as an alternative to rodents, suitable to investigate growth, progression and metastasis of various types of cancer. In the present work, we grafted three Merkel cell carcinoma (MCC) cell lines onto the avian CAM and monitored tumor growth and development of solid tumor nodules. Morphology of xenograft was characterised histologically and immunohistochemically. Our results demonstrate CAM assay as a useful tool to study MCC pathophysiology. © 2018 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd.
- Find related publications in this database (Keywords)
- Chorioallantoic membrane assay
- MCPyV-LT antigen
- Merkel cell carcinoma