Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trummer, C; Pilz, S; Schwetz, V; Obermayer-Pietsch, B; Lerchbaum, E.
Vitamin D, PCOS and androgens in men: a systematic review.
Endocr Connect. 2018; 7(3): R95-R113.
Doi: 10.1530/EC-18-0009
[OPEN ACCESS]
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Trummer Christian
- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Pilz Stefan
- Theiler-Schwetz Verena
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- Abstract:
- Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men. We performed a systematic literature search in PubMed for relevant English language publications published from January 2012 until September 2017. The vitamin D receptor and vitamin D-metabolizing enzymes are found in reproductive tissues of women and men. In women, vitamin D status has been associated with several features of PCOS. In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin resistance as well as hyperandrogenism. Moreover, results from randomized controlled trials (RCTs) suggest that vitamin D supplementation may be beneficial for metabolic, endocrine and fertility aspects in PCOS. In men, vitamin D status has been associated with androgen levels and hypogonadism. Further, there is some evidence for a favorable effect of vitamin D supplementation on testosterone concentrations, although others failed to show a significant effect on testosterone levels. In summary, vitamin D deficiency is associated with adverse fertility outcomes including PCOS and hypogonadism, but the evidence is insufficient to establish causality. High-quality RCTs are needed to further evaluate the effects of vitamin D supplementation in PCOS women as well as on androgen levels in men. © 2018 The authors.
- Find related publications in this database (Keywords)
- vitamin D
- polycystic ovary syndrome
- testosterone
- randomized controlled trial
- systematic review