Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mieli-Vergani, G; Vergani, D; Baumann, U; Czubkowski, P; Debray, D; Dezsofi, A; Fischler, B; Gupte, G; Hierro, L; Indolfi, G; Jahnel, J; Smets, F; Verkade, HJ; Hadžić, N.
Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.
J Pediatr Gastroenterol Nutr. 2018; 66(2):345-360
Doi: 10.1097/MPG.0000000000001801
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Jahnel Jörg
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- Abstract:
- Paediatric autoimmune liver disease is characterized by inflammatory liver histology, circulating autoantibodies, and increased levels of IgG, in the absence of a known etiology. Three conditions have a likely autoimmune pathogenesis: autoimmune hepatitis (AIH), autoimmune sclerosing cholangitis, and de novo AIH after liver transplantation. Two types of pediatric AIH are recognized according to seropositivity for smooth muscle and/or antinuclear antibody (AIH-1) or liver kidney microsomal type 1 and/or anti-liver cytosol type 1 antibodies (AIH-2).Pertinent issues addressing the diagnosis, treatment, and long-term follow-up were formulated by a core group of ESPGHAN members. They have commissioned the first authors with execution of this project. Initially, they have performed a systematic literature search on MEDLINE, ResearchGate, and Mendeley databases during the last 30 years and produced a document focusing on prospective and retrospective studies in children. The ESPGHAN core group and ESPGHAN Hepatology Committee members voted on each recommendation, using a formal voting technique.
- Find related publications in this database (using NLM MeSH Indexing)
- Advisory Committees -
- Autoantibodies - metabolism
- Child -
- Female -
- Gastroenterology -
- Hepatitis, Autoimmune - diagnosis
- Hepatitis, Autoimmune - therapy
- Humans -
- Immunosuppressive Agents - therapeutic use
- Liver - pathology
- Liver Transplantation -
- Male -
- Practice Guidelines as Topic -
- Find related publications in this database (Keywords)
- autoimmune hepatitis
- autoimmune liver disease
- autoimmune sclerosing cholangitis
- children
- pediatric