Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Meyer Sauteur, PM; Moeller, A; Relly, C; Berger, C; Plecko, B; Nadal, D; Swiss Pediatric Surveillance Unit (SPSU).
Swiss national prospective surveillance of paediatric Mycoplasma pneumoniae-associated encephalitis.
Swiss Med Wkly. 2016; 146(1): w14222-w14222.
Doi: 10.4414/smw.2016.14222
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- Co-Autor*innen der Med Uni Graz
- Plecko Barbara
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- Abstract:
- To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis. M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted a nationwide surveillance 2013-2015. Case definition included confirmed, probable and possible cases. Seven patients (median age 8.7 years, range 4.7-10.1 years) with confirmed or possible M. pneumoniae-associated encephalitis were observed. All patients manifested prodromal respiratory symptoms over at least 5 days and five out of the six who had a chest radiograph, showed pulmonary infiltrates. M. pneumoniae DNA in cerebrospinal fluid was negative in all patients. Intrathecally synthesised M. pneumoniae-specific immunoglobulin (IgM and IgG) were investigated and found positive in one patient (confirmed case). M. pneumoniae DNA in respiratory specimens and/or M. pneumoniae-specific IgM and IgG in serum were detected in the other six patients (possible cases). One confirmed and two possible cases had neurological sequelae at 4-19 months follow-up. The lack of detectable M. pneumoniae DNA in cerebrospinal fluid of our encephalitis patients suggests a likely immune-mediated pathogenesis ignited by a respiratory inflammatory process including pneumonia.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Bacterial - cerebrospinal fluid
- Child -
- Child, Preschool -
- DNA, Bacterial - cerebrospinal fluid
- Female -
- Humans -
- Immunoglobulin G - cerebrospinal fluid
- Immunoglobulin M - cerebrospinal fluid
- Infectious Encephalitis - diagnosis
- Infectious Encephalitis - epidemiology
- Infectious Encephalitis - immunology
- Male -
- Mycoplasma Infections - diagnosis
- Mycoplasma Infections - epidemiology
- Mycoplasma Infections - immunology
- Mycoplasma pneumoniae - genetics
- Mycoplasma pneumoniae - immunology
- Pneumonia, Mycoplasma - diagnosis
- Pneumonia, Mycoplasma - epidemiology
- Pneumonia, Mycoplasma - immunology
- Prospective Studies -
- Retrospective Studies -
- Switzerland - epidemiology
- Find related publications in this database (Keywords)
- children
- encephalitis
- epidemiology
- Mycoplasma pneumoniae
- pneumonia