Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jiang, H; Sitoci-Ficici, KH; Reinshagen, C; Molcanyi, M; Zivcak, J; Hudak, R; Laube, T; Schnabelrauch, M; Weisser, J; Schäfer, U; Pinzer, T; Schackert, G; Zhang, X; Wähler, M; Brautferger, U; Rieger, B.
Adjustable Polyurethane Foam as Filling Material for a Novel Spondyloplasty: Biomechanics and Biocompatibility.
World Neurosurg. 2018; 112:e848-e858-e848-e858
Doi: 10.1016/j.wneu.2018.01.174
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Molcanyi Marek
- Schäfer Ute
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- Abstract:
- To investigate the biomechanics and biocompatibility of polyurethane (PU) foam with adjustable stiffness as a filling material for a novel spondyloplasty that is designed to reduce the risk of postoperative adjacent level fractures. Sixty individual porcine lumbar vertebrae were randomly split into 4 groups: A, B, C, and D. Group A served as unmodified vertebral body controls. Groups B, C, and D consisted of hollowed vertebral bodies. Vertebrae of groups C and D were filled with adjustable PU foams of different stiffness. The compressive strength and stiffness of vertebrae from groups A-D were recorded and analyzed. 3T3 mouse fibroblasts were cultured with preformed PU foams for 4 days to test biocompatibility. The strength and stiffness of the hollowed groups were lower than in group A. However, the differences were not statistically significant between group A and group C (P > 0.05), and were obviously different between group A and group B or group D (P < 0.01 and <0.05, respectively). Moreover, the strength and stiffness after filling foams in group C or group D were significantly greater than in group B (P < 0.01 and <0.05, respectively). Live/dead staining of 3T3 cells confirmed the biocompatibility of the PU foam. The new PU foam shows adaptability regarding its stiffness and excellent cytocompatibility in vitro. The results support the clinical translation of the new PU foams as augmentation material in the development of a novel spondyloplasty. Copyright © 2018 Elsevier Inc. All rights reserved.
- Find related publications in this database (Keywords)
- Biokinemetrie
- PMMA
- Polyurethane foam
- Vertebral compression fracture
- Vertebroplasty