Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Loimer, N; Hofmann, P; Chaudhry, HR.
Midazolam shortens seizure duration following electroconvulsive therapy.
J PSYCHIAT RES. 1992; 26(2): 97-101.
Doi: 10.1016%2F0022-3956%2892%2990001-5
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- Co-Autor*innen der Med Uni Graz
- Hofmann Peter
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- Abstract:
- In an open, prospective clinical trial, midazolam anaesthesia was compared with thiopental (plus suxamethonium chloride as a muscle relaxant) to clinically evaluate the former as an anaesthetic and a muscle relaxant during electroconvulsive therapy (ECT). Twelve depressed patients underwent a course of ECT, receiving midazolam or thiopental anaesthesia alternatively. Significant differences were found in seizure duration between the two anaesthetics. Midazolam shortened the seizures to a duration that was not therapeutically desirable. There were no differences in stimulus parameters between the two groups. The muscle relaxant effect of midazolam failed to provide optimal paralysis. Thus, midazolam anaesthesia offers no advantage over standard anaesthetic agents for ECT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anesthesia, General -
- Depressive Disorder - psychology
- Electroconvulsive Therapy - psychology
- Electroencephalography - drug effects
- Evoked Potentials - drug effects
- Female - drug effects
- Humans - drug effects
- Male - drug effects
- Midazolam - administration and dosage
- Prospective Studies - administration and dosage
- Thiopental - administration and dosage