Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Dobsak, T; Heimel, P; Tangl, S; Schwarze, UY; Schett, G; Gruber, R.
Impaired periodontium and temporomandibular joints in tumour necrosis factor-α transgenic mice.
J Clin Periodontol. 2017; 44(12):1226-1235
Doi: 10.1111/jcpe.12799
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schwarze Uwe Yacine
- Tangl Stefan
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- Abstract:
- Tumour necrosis factor (TNF)-α is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis. In this study, we describe the phenotypes of human TNF-α transgenic mice (hTNFtg) with respect to their periodontium and the temporomandibular joint (TMJ). Periodontal structures, TMJ and skull shape of hTNFtg mice and wild-type (WT) littermates were assessed by microcomputed tomography, automated segmentation, geometric morphometrics and histologic ground sections. We show that hTNFtg mice have an eroded lamina dura and reduced periodontal ligament space compared to (WT) littermates. Transgenic mice further exhibit severe destruction of the TMJ. Geometric morphometrics revealed that hTNFtg mice have a more laterally positioned TMJ with a concomitantly enlarged zygomatic process. Mandibular and maxillary teeth occluded properly. Our findings suggest that chronic inflammation in hTNFtg mice causes destructive changes of the periodontium and the TMJ. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arthritis, Rheumatoid -
- Bone Resorption - pathology
- Humans -
- Inflammation -
- Mice -
- Mice, Transgenic -
- Osteoclasts - pathology
- Periodontal Ligament - anatomy & histology
- Periodontal Ligament - pathology
- Periodontium - anatomy & histology
- Periodontium - diagnostic imaging
- Periodontium - pathology
- Phenotype -
- Skull - anatomy & histology
- Temporomandibular Joint - anatomy & histology
- Temporomandibular Joint - diagnostic imaging
- Temporomandibular Joint - physiology
- Tumor Necrosis Factor-alpha - genetics
- Tumor Necrosis Factor-alpha - physiology
- X-Ray Microtomography -
- Zygoma - anatomy & histology
- Find related publications in this database (Keywords)
- geometric morphometrics
- inflammation
- mouse
- periodontium
- resorption
- rheumatoid arthritis
- temporomandibular joints
- transgenic
- tumour necrosis factor-