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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kuchler, U; Keibl, C; Fügl, A; Schwarze, UY; Tangl, S; Agis, H; Gruber, R.
Dimethyloxalylglycine lyophilized onto bone substitutes increase vessel area in rat calvarial defects.
Clin Oral Implants Res. 2015; 26(5):485-491
Doi: 10.1111/clr.12474
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schwarze Uwe Yacine
- Tangl Stefan
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- Abstract:
- Pharmacological inhibitors of prolyl hydroxylases, also termed hypoxia-mimetic agents (HMAs), when repeatedly injected can support angiogenesis and bone regeneration. However, the possible role of HMA loaded onto bone substitutes to support angiogenesis and bone regeneration under diabetic condition is unknown. The capacity of HMA loaded onto deproteinized bovine bone mineral (DBBM) to support angiogenesis and bone formation was examined in diabetic Wistar rats. Diabetes was induced by intraperitoneal injection of streptozotocin. The HMA dimethyloxalylglycine (DMOG) and desferrioxamine (DFO) were lyophilized onto DBBM. Calvarial defects were created with a trephine drill and filled with the respective bone substitutes. After 4 weeks of healing, the animals were subjected to histological and histomorphometric analysis. In this report, we provide evidence that DMOG loaded onto DBBM can support angiogenesis in vivo. Specifically, we show that DMOG increased the vessel area in the defect site to 2.4% ± 1.3% compared with controls 1.1% ± 0.48% (P = 0.012). There was a trend toward an increased vessel number in the defect site with 38.6 ± 17.4 and 31.0 ± 10.3 in the DMOG and the control group (P = 0.231). The increase in angiogenesis, however, did not translate into enhanced bone formation in the defect area with 9.2% ± 7.1% and 8.4% ± 5.6% in DMOG and control group, respectively. No significant changes were caused by DFO. The results suggest that DMOG loaded onto DBBM can support angiogenesis, but bone formation does not increase accordingly in a type 1 diabetic rat calvarial defect model at the indicated time point. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiogenesis Inducing Agents - pharmacology
- Animals -
- Bone Regeneration - drug effects
- Bone Substitutes - chemistry
- Deferoxamine - pharmacology
- Diabetes Mellitus, Experimental - physiopathology
- Glycine - analogs & derivatives
- Glycine - pharmacology
- Male -
- Neovascularization, Physiologic - drug effects
- Rats -
- Rats, Wistar -
- Skull - blood supply
- Find related publications in this database (Keywords)
- Bio-Oss
- bone regeneration
- calvaria
- desferrioxamine angiogenesis
- diabetes
- dimethyloxalylglycine
- natural bone mineral
- prolyl hydroxylase
- rat