Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Flaim, C; Kob, M; Di Pierro, AM; Herrmann, M; Lucchin, L.
Effects of a whey protein supplementation on oxidative stress, body composition and glucose metabolism among overweight people affected by diabetes mellitus or impaired fasting glucose: A pilot study.
J Nutr Biochem. 2017; 50(6):95-102
Doi: 10.1016/j.jnutbio.2017.05.003
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans & Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. 2007]. WP have unpleasant taste and smell [Patel 2015], but a new WP isolate (ProLYOtin®) seems to be more palatable. 40 g/die of ProLYOtin® were supplemented to overweight people (n=31) with impaired fasting glucose/DM2 for 12 weeks. Markers of antioxidant status (total antioxidant status, glutathione peroxidase, glutathione reductase, uric acid), oxidative damage (thiobarbituric acid reactive substances, advanced oxidation protein products, 8-hydroxydeoxyguanosine), inflammation (interleukin-6, high sensitive reactive protein C) and glicemic status (fasting glucose, insulin, glycated hemoglobin), anthropometric data (weight, height, waist circumference), body composition (body cell mass, fat mass), blood pressure, hand grip strength and skin autofluorescence were measured before and at the end of supplementation. Isolate palatability was evaluated. An increase in glutathione peroxidase, a decrease in uric acid and no change in glutathione reductase, total antioxidant status, oxidative damage, inflammation and glucose markers were found. Significant improvements in anthropometric parameters and fat mass were detected. There wasn't any change in blood pressure, skin autofluorescence and physical performance. Two-thirds of subjects judged the supplement positively. ProLYOtin® seems suitable for treatment of OS and overweight. Copyright © 2017 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adiposity -
- Aged -
- Antioxidants - adverse effects
- Antioxidants - therapeutic use
- Biomarkers - blood
- Body Mass Index -
- Diabetes Mellitus, Type 2 - blood
- Diabetes Mellitus, Type 2 - complications
- Diabetes Mellitus, Type 2 - diet therapy
- Dietary Supplements - adverse effects
- Female -
- Food Preferences -
- Glucose Intolerance - blood
- Glucose Intolerance - complications
- Glucose Intolerance - diet therapy
- Hand Strength -
- Humans -
- Hyperglycemia - prevention & control
- Italy -
- Male -
- Middle Aged -
- Obesity - blood
- Obesity - complications
- Obesity - diet therapy
- Overweight - blood
- Overweight - complications
- Overweight - diet therapy
- Oxidative Stress -
- Pilot Projects -
- Waist Circumference -
- Whey Proteins - adverse effects
- Whey Proteins - therapeutic use
- Find related publications in this database (Keywords)
- Whey proteins
- Oxidative stress
- Body composition
- Glucose metabolism
- Skin autofluorescence
- Palatability