Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Todenhöfer, T; Hennenlotter, J; Feyerabend, S; Aufderklamm, S; Mischinger, J; Kühs, U; Gerber, V; Fetisch, J; Schilling, D; Hauch, S; Stenzl, A; Schwentner, C.
Preliminary experience on the use of the Adnatest® system for detection of circulating tumor cells in prostate cancer patients.
Anticancer Res. 2012; 32(8):3507-3513
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Mischinger Johannes
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- Abstract:
- The Adnatest® system combines immunomagnetic enrichment of epithelial cells with polymerase chain reaction for prostate cancer (PC)-specific transcripts for the detection circulating tumor cells (CTCs). We evaluated the Adnatest® in patients with castration-resistant PC receiving docetaxel chemotherapy. CTCs were assessed in 16 patients with castration-resistant PC before cycles one and three of chemotherapy. Furthermore, markers of stem cells and epithelial-mesenchymal transition were assessed. Treatment response was assessed by imaging and prostate-specific antigen measurements. Before chemotherapy, 11 patients were Adnatest®-positive whereas five patients were Adnatest®-positive before cycle three. A positive Adnatest® correlated with radiological progression (p=0.02). Rates of disease progression in epidermal growth factor receptor (EGFR)-positive and -negative patients were 100% and 7.7% (p=0.03). In this preliminary study, the Adnatest® detected CTCs in a considerable proportion of patients with castration-resistant PC. First data on certain markers (EGFR and aldehyd dehydrogenase 1) encourage future studies investigating transcripts predicting treatment response.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antineoplastic Agents - therapeutic use
- Humans -
- Male -
- Middle Aged -
- Neoplastic Cells, Circulating -
- Polymerase Chain Reaction -
- Prostatic Neoplasms - blood
- Prostatic Neoplasms - drug therapy
- Prostatic Neoplasms - pathology
- RNA, Messenger - genetics
- Taxoids - therapeutic use
- Find related publications in this database (Keywords)
- Adnatest
- CTC
- chemotherapy
- prostate cancer
- response
- prognosis