Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gakis, G; Morgan, TM; Efstathiou, JA; Keegan, KA; Mischinger, J; Todenhoefer, T; Schubert, T; Zaid, HB; Hrbacek, J; Ali-El-Dein, B; Clayman, RH; Galland, S; Olugbade, K; Rink, M; Fritsche, HM; Burger, M; Chang, SS; Babjuk, M; Thalmann, GN; Stenzl, A; Daneshmand, S.
Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma.
World J Urol. 2016; 34(1):97-103
Doi: 10.1007/s00345-015-1583-7
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- Co-Autor*innen der Med Uni Graz
- Mischinger Johannes
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- Abstract:
- To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC). A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality
- Adenocarcinoma - pathology
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- Age Factors -
- Aged -
- Carcinoma, Squamous Cell - mortality
- Carcinoma, Squamous Cell - pathology
- Carcinoma, Squamous Cell - therapy
- Carcinoma, Transitional Cell - mortality
- Carcinoma, Transitional Cell - pathology
- Carcinoma, Transitional Cell - therapy
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- Disease-Free Survival -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
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- Urethral Neoplasms - mortality
- Urethral Neoplasms - pathology
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- Clinical
- Nodal stage
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- Prognostic
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