Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aufderklamm, S; Todenhöfer, T; Hennenlotter, J; Gakis, G; Mischinger, J; Mundhenk, J; Germann, M; Stenzl, A; Schwentner, C.
Bilateral laparoscopic postchemotherapy retroperitoneal lymph-node dissection in nonseminomatous germ cell tumors--a comparison to template dissection.
J Endourol. 2013; 27(7):856-861
Doi: 10.1089/end.2012.0648
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Mischinger Johannes
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- Abstract:
- Retroperitoneal lymph node dissection (RPLND) is performed in patients with advanced nonseminomatous (NSGCT) germ cell tumors and residual retroperitoneal mass post-chemotherapy. The extent of node dissection remains unclear. Ipsilateral template dissection is a compromise between morbidity and oncological efficacy. Here, we compare ipsilateral with primary bilateral laparoscopic (L)-RPLND after chemotherapy in terms of morbidity and oncological safety. Nineteen laparoscopic ipsilateral L-RPLNDs (Group A) after platinum-based chemotherapy in patients with clinical stage IIA-III NSGCT were performed, while 20 patients underwent primary bilateral L-RPLND (Group B). We included patients with residuals localized in the retroperitoneum >1 cm and a tumor marker negativity after chemotherapy. The patients in group B had nerve sparing based on their respective tumor volume. All L-RPLND was successfully finished without conversion. Mean operative time in group A was 221 minutes and 270 minutes in group B (p=0.12). There were no deviations from the normal postoperative course in 36 cases. There was one Grade II complication (bleomycin-induced pneumonitis) in group A and 1 grade III complication (chylous ascites) in group B. The mean hospitalization time in both groups was 5 days (p=0.1). With regard to the overall rate of disease recurrence, no significant difference was found between both groups (HR=1.84; 95% CI 0.17-39.92; p=0.6109). Postchemotherapy L-RPLND remains technically challenging. However, the morbidity of primary bilateral post-chemotherapy L-RPLND is similar to that of template dissection. Additional oncological safety is provided, which is particularly relevant in patients with more extensive retroperitoneal tumor volume.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antineoplastic Agents - therapeutic use
- Follow-Up Studies -
- Humans -
- Laparoscopy - methods
- Lymph Node Excision - methods
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Staging -
- Neoplasms, Germ Cell and Embryonal - diagnosis
- Neoplasms, Germ Cell and Embryonal - secondary
- Neoplasms, Germ Cell and Embryonal - therapy
- Retroperitoneal Space -
- Retrospective Studies -
- Testicular Neoplasms - pathology
- Testicular Neoplasms - therapy
- Tomography, X-Ray Computed -
- Treatment Outcome -
- Young Adult -