Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kaufmann, S; Mischinger, J; Amend, B; Rausch, S; Adam, M; Scharpf, M; Fend, F; Kramer, U; Notohamiprodjo, M; Nikolaou, K; Stenzl, A; Bedke, J; Kruck, S.
First report of robot-assisted transperineal fusion versus off-target biopsy in patients undergoing repeat prostate biopsy.
World J Urol. 2017; 35(7):1023-1029
Doi: 10.1007/s00345-016-1970-8
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Mischinger Johannes
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- Abstract:
- To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System. A robot-assisted system was utilized to collect four robot-assisted targeted transperineal biopsy cores (RA-TB) within the lesion using mpMRI-TRUS elastic fusion. Untargeted transperineal 14-core biopsy was performed only outside the lesion (RA-UB). Histological grade was compared in biopsies and available prostatectomy specimens. Overall, 34 of 55 patients (62%) were diagnosed with PC based on biopsy. 85% of cancers were clinically significant PC (csPC) defined as GS ≥ 7. 85% of biopsy-proven cancers were detected with RA-TB alone. RA-UB identified only one additional patient with csPC and lead to upgrading in five biopsy cases (14.7%). Pathological evaluation of 14 prostatectomy specimens showed upgrading in 2 patients (14.3%), while all other patients were correctly classified by RA-TB without need of additional RA-UB. Mean procedure duration was 43 (±6) min, and only minor complications according to Clavien-Dindo were recorded during 30-day follow-up. This is the first report of transperineal robot-assisted elastic mpMRI-TRUS fusion biopsy. RA-TB of positive MR lesions enabled reliable detection of csPC, while RA-UB in MRI-negative regions is of minor importance.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Humans -
- Image-Guided Biopsy - instrumentation
- Image-Guided Biopsy - methods
- Imaging, Three-Dimensional - methods
- Magnetic Resonance Imaging - instrumentation
- Magnetic Resonance Imaging - methods
- Male -
- Middle Aged -
- Neoplasm Grading -
- Prostate - diagnostic imaging
- Prostate - pathology
- Prostatectomy - methods
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - pathology
- Reproducibility of Results -
- Robotics - methods
- Ultrasonography, Interventional - instrumentation
- Ultrasonography, Interventional - methods
- Find related publications in this database (Keywords)
- Robotics
- Prostate cancer
- Biopsy
- 3D imaging
- MR-guided interventional procedures