Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aufderklamm, S; Todenhöfer, T; Hennenlotter, J; Mischinger, J; Sim, A; Böttge, J; Rausch, S; Bier, S; Halalsheh, O; Stenzl, A; Gakis, G; Schwentner, C.
Complex residual tumors after chemotherapy of nonseminomatous germ cell tumors. Laparoscopic management - limits and chances].
Urologe A. 2015; 54(7):1002-1009
Doi: 10.1007/s00120-014-3616-z
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Mischinger Johannes
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- Abstract:
- Laparoscopic retroperitoneal lymph node dissection (L-RPLND) is often required in patients with metastatic nonseminomatous germ cell tumors (NSGCT) and residual tumors after chemotherapy. Laparoscopy has become established as a safe procedure in the surgical management of these tumors. Due to the rapid development of laparoscopy, complex retroperitoneal and even intrathoracic residuals can also be treated in high volume centers. This study included 21 retrospectively identified NSGCT and seminoma patients (mean age 29 years) with metastatic disease and clinical stage (CS) IIA-IIIB. A bilateral L-RPLND was performed in all male patients between 2009 and 2014. In 19 patients an infiltration of the great vessels was detected during surgery and vascular reconstruction was necessary. In 2 patients an intrathoracic residual 5.4 cm and 7 cm in size, respectively, was diagnosed during follow-up. Exclusion criteria for L-RPLND were positive tumor markers after chemotherapy, patients with local recurrence after previous open L-RPLND and patients with excessive vascular involvement. In this series no conversions to open surgery were necessary. The mean tumor size post-chemotherapy was 3.6 cm (range 1.5-9.7 cm). The mean measured blood loss was 294 ml (range 50-1000 ml). The mean hospitalization time was 6 days (range 3-9 days) and mean follow-up was 16 months (range 1-37 months). No complications higher than grade II (Clavien-Dindo classification) were registered in the immediate postoperative course. During the follow-up period no in-field recurrences were registered. The L-RPLND seems to be a safe alternative surgical procedure for certain complex residuals with vascular involvement after chemotherapy of testicular cancer. Bilateral L-RPLND is technically feasible and reproducible under guaranteed oncological principles. An infiltration of the great vessels and also intrathoracic residuals can be managed in selected patients without compromising the clinical and oncological course.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antineoplastic Agents - therapeutic use
- Feasibility Studies -
- Humans -
- Laparoscopy - methods
- Male -
- Middle Aged -
- Neoplasm, Residual -
- Neoplasms, Germ Cell and Embryonal - pathology
- Neoplasms, Germ Cell and Embryonal - therapy
- Retrospective Studies -
- Seminoma - pathology
- Seminoma - therapy
- Testicular Neoplasms - pathology
- Testicular Neoplasms - therapy
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Lymphadenectomy
- Chemotherapy
- Testicular cancer
- Stage IIc
- Laparoscopy