Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aufderklamm, S; Hennenlotter, J; Todenhöfer, T; Senghaas, N; Scharpf, M; Gakis, G; Rausch, S; Mischinger, J; Bier, S; Stenzl, A; Schwentner, C; Bedke, J.
Oncologic Impact of Renal Tissue Adjacent to Renal Cell Carcinoma.
Anticancer Res. 2016; 36(6):2865-2869
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Mischinger Johannes
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- The aim of the study was to investigate the clinical impact of the surgical margin width after nephron-sparing surgery (NSS) on the oncological course of renal cell carcinoma (RCC). The study comprised of 126 RCC patients with NSS between 2002 and 2009. Inclusion criteria were negative resection margins and a tumor diameter of ≤100 mm with the possibility of a complete circumferential histopathological reevaluation. The minimal benign margin width was correlated to the patients' clinical course. Median safety margin width was revealed to be 1 mm. Nine of 126 patients (7.1%) developed recurrent disease (five local, four distant). All patients with local recurrence had safety margins ≤1 mm, whereas out of 49 patients with a margin >1 mm no one developed local recurrence (p=0.0245). Safety margin ≤1 mm showed associations with increased risk for overall recurrence in univariate and multivariate analysis (p=0.0531 and 0.0539, respectively). Tumor adjacent renal parenchyma may have oncological relevance, corroborating the need for further molecular investigation of tumor-adjacent tissue in RCC. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Renal Cell - surgery
- Female -
- Humans -
- Kidney Neoplasms - surgery
- Male -
- Margins of Excision -
- Middle Aged -
- Neoplasm Recurrence, Local - etiology
- Nephrons - surgery
- Find related publications in this database (Keywords)
- Renal cell carcinoma
- nephron-sparing surgery
- parenchyma
- safety margin
- recurrence
- oncological outcome