Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rausch, S; Hennenlotter, J; Scharpf, M; Teepe, K; Kühs, U; Aufderklamm, S; Bier, S; Mischinger, J; Gakis, G; Stenzl, A; Schwentner, C; Todenhöfer, T.
Prostate tumor overexpressed 1 expression in invasive urothelial carcinoma.
J Cancer Res Clin Oncol. 2016; 142(5):937-947
Doi: 10.1007/s00432-015-2107-y
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Mischinger Johannes
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- Abstract:
- To determine the expression patterns of the proliferation marker prostate tumor overexpressed 1 (PTOV1) in invasive urothelial cancer (UC). Corresponding UC and benign samples from paraffin-embedded tissue of 102 patients treated with cystectomy for invasive UC were immunohistochemically (IHC) assessed for PTOV1. Expression was evaluated gradually separated for cytoplasmic and nuclear staining. Results were correlated to histological and clinical data. To correlate PTOV1 expression with molecular subtypes of UC, analysis of PTOV1 RNA expression data of the Cancer Genome Atlas UC cohort was performed. PTOV1 expression was present in UC and benign urothelium, whereby nuclear staining was significantly more frequent in UC tissue (p = 0.0004). Lower cytoplasmic expression was significantly associated with pathological stage >pT2 (p = 0.0014) and grade ≥G3 (p = 0.0041), respectively. IHC expression patterns did not show correlation to survival data. PTOV1 RNA expression correlated with features of the luminal UC subtype. Subcellular distribution seems to be the most important feature of PTOV1 expression in UC. Nuclear localization of PTOV1 along with cytoplasmic decrease in PTOV1 expression was identified as putative surrogate for PTOV1-associated cellular proliferation and dedifferentiation in UC. The functional relevance as well as the potential role of PTOV1 as a biomarker in UC remains to be specified in future studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - genetics
- Biomarkers, Tumor - metabolism
- Carcinoma in Situ - genetics
- Carcinoma in Situ - metabolism
- Carcinoma in Situ - pathology
- Case-Control Studies -
- Female -
- Follow-Up Studies -
- High-Throughput Nucleotide Sequencing -
- Humans -
- Immunoenzyme Techniques -
- Male -
- Middle Aged -
- Neoplasm Grading -
- Neoplasm Invasiveness -
- Neoplasm Proteins - genetics
- Neoplasm Proteins - metabolism
- Neoplasm Staging -
- Prognosis -
- Prostatic Neoplasms - genetics
- Prostatic Neoplasms - metabolism
- Prostatic Neoplasms - pathology
- Survival Rate -
- Urologic Neoplasms - genetics
- Urologic Neoplasms - metabolism
- Urologic Neoplasms - pathology
- Urothelium - metabolism
- Urothelium - pathology
- Find related publications in this database (Keywords)
- Biomarker
- Bladder cancer
- Immunohistochemistry
- Proliferation
- PTOV1