Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schönbach, EM; Ibrahim, MA; Kong, X; Strauss, RW; Muñoz, B; Birch, DG; Sunness, JS; West, SK; Scholl, HPN.
Metrics and Acquisition Modes for Fixation Stability as a Visual Function Biomarker.
Invest Ophthalmol Vis Sci. 2017; 58(6): BIO268-BIO276.
Doi: 10.1167/iovs.17-21710
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Strauß Rupert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- To compare different metrics and acquisition modes of fixation stability as a new visual function biomarker in a large cohort of patients with ABCA4-related Stargardt disease from the multicenter prospective ProgStar study. Fixation was tested during a separate fixation exam and also dynamically during a sensitivity exam, using fundus-tracking microperimetry (Nidek MP-1). Fixation data were analyzed using the bivariate contour ellipse area (BCEA), the 2/4 degree method, and the Fujii classification. In a total of 235 patients, the mean BCEA was larger when measured during the sensitivity exam (418 eyes; 12.5 vs. 4.6 deg2 during the fixation task in 427 eyes). Correlations between the two tests were generally weak. Fixation stability during the sensitivity test was significantly correlated with visual acuity. Comparing the BCEA values and the corresponding Fujii categories for these eyes revealed ranges of overlap where an eye with one defined BCEA value can fall into each of the three Fujii categories. Patients may have limited ability to fixate over defined time periods, which leads to significant differences between shorter and longer measurements of fixation stability. The most appropriate way to use this functional biomarker appears to be using continuous metrics for fixation stability, such as the BCEA, during a macular sensitivity test.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers -
- Female -
- Fixation, Ocular - physiology
- Humans -
- Macula Lutea - physiology
- Macular Degeneration - congenital
- Macular Degeneration - diagnosis
- Macular Degeneration - physiopathology
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Prospective Studies -
- Sensitivity and Specificity -
- Visual Acuity - physiology
- Visual Field Tests - methods
- Visual Fields - physiology
- Young Adult -
- Find related publications in this database (Keywords)
- fixation
- Fujii method
- fundus-tracking microperimetry
- BCEA
- Stargardt