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SHR Neuro Cancer Cardio Lipid Metab Microb

Jockel-Schneider, Y; Bechtold, M; Haubitz, I; Störk, S; Fickl, S; Harks, I; Eigenthaler, M; Vollrath, O; Baulmann, J; Schlagenhauf, U.
Impact of anti-infective periodontal therapy on parameters of vascular health.
J Clin Periodontol. 2018; 45(3):354-363 Doi: 10.1111/jcpe.12849
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Co-authors Med Uni Graz: Baulmann Johannes
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Abstract:: This study assessed the impact of anti-infective periodontal therapy on the status of vascular health. Periodontal and vascular health of 55 patients with severe untreated chronic periodontitis was evaluated before and 12 months after anti-infective periodontal therapy. Observed parameters were bleeding on probing (BoP), pocket probing depth (PPD), periodontal inflamed surface area index (PISA), pulse wave velocity (PWV), augmentation index (AIx), central pulse pressure (PPao) and peripheral systolic pressure (RRsys). ΔPISA (baseline-12 months) correlated with ΔPWV (τ 0.21; p < .03), ΔAIx (τ 0.29; p < .002) and ΔPPao (τ 0.23; p < .02). ΔBoP% (baseline-12 months) correlated with ΔPWV (τ 0.18; p < .05) and ΔAIx (τ 0.25; p < .01), while mean ΔPPD (baseline-12 months) correlated with ΔPWV (τ 0.24; p < .01) and ΔAIx (τ 0.21; p < .03). Grouping patients evenly into three groups based on tertiles of BoP resolution after 12 months revealed a significant decrease in the observed PWV median value by -0.6 m/s (p < .04) in the best response tertile (ΔBoP ≥ 88%). In the worst response tertile (ΔBoP ≤ 66%), by contrast, significant increase in PPao (+10.5 mmHg; p < .02) and AIx (+5.5; p < .02) was observed. Efficacious resolution of periodontal inflammation may beneficially impact on vascular health. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (Keywords): arterial stiffness; central blood pressure; inflammation; periodontal therapy; periodontitis; pulse wave velocity