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SHR Neuro Cancer Cardio Lipid Metab Microb
Franzen, M; Moré, E; Cadamuro, J; Koller, J; Salmhofer, W; Wohlmuth-Wieser, I; Kronberger, C; Salmhofer, H.
Mineral Depositions of Calcifying Skin Disorders are Predominantly Composed of Carbonate Apatite.
Acta Derm Venereol. 2017; 97(10):1178-1181
Doi: 10.2340/00015555-2739
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- Leading authors Med Uni Graz
- Salmhofer Wolfgang
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- Abstract:
- Subcutaneous calcifications can lead to complications, including pain, inflammation, ulceration and immobilization. Studies on the pathophysiology of mineral compositions and effective treatment modalities are limited. We therefore studied 14 patients with subcutaneous calcifications. Mineral material was collected and analysed by Fourier transform infrared spectrometry. Blood analyses were run to evaluate systemic alterations of mineral metabolism. Carbonate apatite (CAP) was found to be the single constituent in the majority of patients (n = 9, 64.3%), 3 cases (21.4%) had a composition of CAP and calcium oxalate dihydrate and one case had a combination of CAP and magnesium ammonium phosphate, whereas CAP was the major component in all 4 cases. Only one case showed predominantly calcium oxalate. Thus, CAP was found to be the only or predominant component in most cases of subcutaneous calcifications. Chemical analyses of the mineral compositions may aid in the development of new treatment regimes to improve the solubility of mineral components and to decrease extraosseous calcifications.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Apatites - analysis
- Calcinosis - diagnostic imaging
- Calcinosis - metabolism
- Female -
- Humans -
- Male -
- Middle Aged -
- Retrospective Studies -
- Skin - chemistry
- Skin - diagnostic imaging
- Skin Diseases - diagnostic imaging
- Skin Diseases - metabolism
- Spectroscopy, Fourier Transform Infrared -
- Subcutaneous Tissue - chemistry
- Subcutaneous Tissue - diagnostic imaging
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- subcutaneous calcifications
- tumoural calcinosis
- carbonate apatite