Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moser, O; Münzker, J; Korsatko, S; Pachler, C; Smolle, K; Toller, W; Augustin, T; Plank, J; Pieber, TR; Mader, JK; Ellmerer, M.
A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery.
Sci Rep. 2018; 8(1):1262-1262
Doi: 10.1038/s41598-018-19768-2
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- Führende Autor*innen der Med Uni Graz
- Mader Julia
- Moser Othmar
- Münzker Julia
- Co-Autor*innen der Med Uni Graz
- Ellmerer Martin
- Korsatko Stefan
- Pachler Christoph
- Pieber Thomas
- Smolle Karl-Heinz
- Toller Wolfgang
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- Abstract:
- We evaluated a standard subcutaneous microdialysis technique for glucose monitoring in two critically ill patient populations and tested whether a prolonged run-in period improves the quality of the interstitial glucose signal. 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ± 3.2) and 10 medical patients with severe sepsis (APACHE II score: 31.1 ± 4.3) were included in this investigation. A microdialysis catheter was inserted in the subcutaneous adipose tissue of the abdominal region. Interstitial fluid and arterial blood were sampled in hourly intervals to analyse glucose concentrations. Subcutaneous adipose tissue glucose was prospectively calibrated to reference arterial blood either at hour 1 or at hour 6. Median absolute relative difference of glucose (MARD), calibrated at hour 6 (6.2 (2.6; 12.4) %) versus hour 1 (9.9 (4.2; 17.9) %) after catheter insertion indicated a significant improvement in signal quality in patients after major cardiac surgery (p < 0.001). Prolonged run-in period revealed no significant improvement in patients with severe sepsis, but the number of extreme deviations from the blood plasma values could be reduced. Improved concurrence of glucose readings via a 6-hour run-in period could only be achieved in patients after major cardiac surgery.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Blood Glucose - metabolism
- Cardiac Surgical Procedures - adverse effects
- Clinical Trials as Topic -
- Critical Illness -
- Extracellular Fluid - metabolism
- Female -
- Humans -
- Male -
- Microdialysis - methods
- Microdialysis - standards
- Middle Aged -
- Monitoring, Physiologic - methods
- Monitoring, Physiologic - standards
- Postoperative Complications - blood
- Sepsis - blood