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Schneditz, D; Sarikakis, G; Kontodima, M; Sauseng, N.
The Influence of Colloid Osmotic Pressure on Hydrostatic Pressures in High- and Low-Flux Hemodialyzers.
Artif Organs. 2018; 42(5):525-532 Doi: 10.1111/aor.13081 [OPEN ACCESS]
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Leading authors Med Uni Graz: Schneditz Daniel
Co-authors Med Uni Graz: Sauseng Notburga
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Abstract:: The aim of this study was to examine the relationship between hydrostatic trans-membrane pressure (TMP_h ) and colloid osmotic pressure (COP) in low-flux (LF) and high-flux (HF) dialyzers. Hydrostatic pressures were measured in dialyzers distinguished by their ultrafiltration coefficient K_uf (16 and 85 mL/h/mm Hg) under constant dialysate flow and variable blood flow (Q_b ) ranging from 0 to 400 mL/min using (i) alginate (70 kDa) dissolved in dialysate, (ii) diluted, undiluted, and concentrated plasma, or (iii) whole blood at different hematocrit, all in absence of ultrafiltration (UF). For a given fluid, TMP_h linearly increased with increasing Q_b . The intercept of the linear TMP_h to Q_b relationship correlated with measured COP with an average bias of 1.00 ± 2.26 mm Hg and a concordance correlation coefficient of 0.98. The slope of the linear TMP_h to Q_b relationship increased with increasing sample viscosity and was much larger in HF dialyzers under otherwise identical operating conditions, most likely because of increased internal filtration. The TMP_h to Q_b relationship measured in dialyzers in absence of UF can be described by the intercept related to measured COP and the slope related to internal filtration. This relationship could be of interest to estimate internal filtration and COP under in vivo conditions. © 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Find related publications in this database (Keywords): High-flux dialyzer; Colloid osmotic pressure; Trans-membrane pressure; Internal filtration; Renal replacement therapy