Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schulz, R; Murzabekova, G; Egemnazarov, B; Kraut, S; Eisele, HJ; Dumitrascu, R; Heitmann, J; Seimetz, M; Witzenrath, M; Ghofrani, HA; Schermuly, RT; Grimminger, F; Seeger, W; Weissmann, N.
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.
J Hypertens. 2014; 32(2):300-305
Doi: 10.1097/HJH.0000000000000016
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Egemnazarov Bakytbek
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- Abstract:
- To investigate whether NADPH oxidase 2 (NOX2), a major source of reactive oxygen species (ROS), contributes to the emergence of arterial hypertension in a murine model of sleep apnea. Obstructive sleep apnea (OSA) is a risk factor for arterial hypertension and it is linked to oxidative stress. C57BL/6J mice were exposed to chronic intermittent hypoxia (CIH) for 6 weeks (5 days/week, 8 h/day, alternating cycles of hypoxia and normoxia, each lasting 120 s, nadir FiO2: 7%). Blood pressure was monitored by telemetric catheters implanted into the abdominal aorta. Pharmacological inhibition of NOX by apocynin and NOX2-deficient mice were used to assess the role of NOX in CIH-induced arterial hypertension. NOX2 gene expression was measured by real-time PCR in different cardiovascular tissues. When compared with room air conditions, wild-type mice showed significant blood pressure elevations after exposure to CIH. This response was attenuated after treating animals with apocynin and in NOX2 (=gp91) knockout mice, whereas NOX2 was not upregulated in the heart, aorta, and femoral/carotid arteries of CIH mice. We suggest that the CIH-induced arterial hypertension is mediated by ROS derived from an activation of NOX2 within cells located outside the cardiovascular system.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetophenones - pharmacology
- Animals -
- Blood Pressure - physiology
- Disease Models, Animal -
- Enzyme Inhibitors - pharmacology
- Hypertension - enzymology
- Hypertension - etiology
- Hypertension - physiopathology
- Male -
- Membrane Glycoproteins - antagonists & inhibitors
- Membrane Glycoproteins - genetics
- Membrane Glycoproteins - physiology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- NADPH Oxidase 2 -
- NADPH Oxidases - antagonists & inhibitors
- NADPH Oxidases - genetics
- NADPH Oxidases - physiology
- Oxidative Stress -
- RNA, Messenger - genetics
- RNA, Messenger - metabolism
- Reactive Oxygen Species - metabolism
- Risk Factors -
- Sleep Apnea, Obstructive - complications
- Sleep Apnea, Obstructive - enzymology
- Find related publications in this database (Keywords)
- arterial hypertension
- mice
- NADPH oxidase
- sleep apnea