Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Krstic, J; Obradovic, H; Kukolj, T; Mojsilovic, S; Okic-Dordevic, I; Bugarski, D; Santibanez, JF.
An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling.
Protein Pept Lett. 2015; 22(7): 570-578.
Doi: 10.2174/0929866522666150520145554
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- Leading authors Med Uni Graz
- Krstic Jelena
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- Abstract:
- Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4+ T cells, which comprises six ligands (IL-17A to IL- 17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Humans -
- Interleukin-17 - chemistry
- Interleukin-17 - metabolism
- Protein Binding -
- Receptors, Interleukin-17 - chemistry
- Receptors, Interleukin-17 - metabolism
- Signal Transduction -
- Find related publications in this database (Keywords)
- Expression
- Interleukin-17
- interleukin-17 receptor A
- receptor interaction
- regulation
- signaling pathways