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SHR Neuro Cancer Cardio Lipid Metab Microb

Trivanović, D; Krstić, J; Jauković, A; Bugarski, D; Santibanez, JF.
Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition.
Dev Dyn. 2018; 247(3):359-367 Doi: 10.1002/dvdy.24583 [OPEN ACCESS]
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Co-authors Med Uni Graz: Krstic Jelena
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Abstract:: Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to mesenchymal transition (EMT) in tumor cells are dependent on their interaction with adjacent or recruited mesenchymal stromal cells (MSCs). A plethora of mechanisms are involved in MSCs-controlled employment of the developmental processes of EMT that contribute to loss of epithelial cell phenotype and acquisition of stemness, invasiveness and chemoresistance of tumor cells. Interplay of MSCs with tumor cells, including interchange of soluble biomolecules, plasma membrane structures, cytoplasmic content, and organelles, is established through cell-cell contact and/or by means of paracrine signaling. The main focus of this review is to summarize knowledge about involvement of MSCs in cancer cell EMT. Understanding the underlying cellular and molecular mechanism involved in the interplay between MSCs and cancer EMT is essential for development of effective therapy approaches, which in combination with current treatments may improve the control of tumor progression. Developmental Dynamics 247:359-367, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Epithelial-Mesenchymal Transition -; Mesenchymal Stem Cells - pathology; Neoplasms - pathology
Find related publications in this database (Keywords): stem cells; mesenchymal stromal cells; cancer; epithelial to mesenchymal transition