Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Đorđević, IO; Kukolj, T; Krstić, J; Trivanović, D; Obradović, H; Santibañez, JF; Mojsilović, S; Ilić, V; Bugarski, D; Jauković, A.
The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs.
Int J Biochem Cell Biol. 2016; 71(3): 92-101.
Doi: 10.1016/j.biocel.2015.12.007
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- Co-authors Med Uni Graz
- Krstic Jelena
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- Abstract:
- Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD. Copyright © 2015 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cell Differentiation - drug effects
- Cell Lineage - drug effects
- Cell Movement - drug effects
- Cell Proliferation - drug effects
- Humans -
- Interleukin-17 - pharmacology
- Mitogen-Activated Protein Kinases - metabolism
- Osteogenesis - drug effects
- Periodontal Ligament - cytology
- Phenotype -
- Signal Transduction - drug effects
- Stem Cells - cytology
- Stem Cells - drug effects
- Young Adult -
- Find related publications in this database (Keywords)
- Interleukin-17
- Periodontal ligament mesenchymal stem cells
- Osteogenic differentiation
- Immunomodulatory capacity