Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Birchbauer, A; Wolf, G; Knipping, G.
Metabolism of very low density lipoproteins in the pig. An in vivo study.
INT J BIOCHEM. 1992; 24(10): 1591-1597.
Doi: 10.1016/0020-711X(92)90175-Z
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- Co-Autor*innen der Med Uni Graz
- Wintersperger Andrea
- Wolf Gerhard
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- Abstract:
- 1. The metabolism of apolipoprotein B (apoB) was investigated in pigs injected with [125I]very low density lipoproteins (VLDL) to determine to which extent the two distinct low density lipoprotein subclasses (LDL1 and LDL2) derive from VLDL. 2. The lipoproteins were isolated by density gradient ultracentrifugation and the transfer of radioactivity from VLDL into LDL1 and LDL2 apoB was measured. 3. Only a minor portion of VLDL apoB was converted to LDL1 (7.7 +/- 3.2%) and LDL2 (3.6 +/- 1.5%), respectively. Thus, we conclude that the major portion of LDL, especially LDL2, is synthesized independently from VLDL catabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apolipoproteins B - blood
- Electrophoresis, Polyacrylamide Gel - blood
- Kinetics - blood
- Lipoproteins, LDL - blood
- Lipoproteins, VLDL - blood
- Male - blood
- Microscopy, Electron - blood
- Swine - blood