Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benedict, RHB; DeLuca, J; Enzinger, C; Geurts, JJG; Krupp, LB; Rao, SM.
Neuropsychology of Multiple Sclerosis: Looking Back and Moving Forward.
J Int Neuropsychol Soc. 2017; 23(9-10):832-842
Doi: 10.1017/S1355617717000959
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
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- Abstract:
- The neuropsychological aspects of multiple sclerosis (MS) have evolved over the past three decades. What was once thought to be a rare occurrence, cognitive dysfunction is now viewed as one of the most disabling symptoms of the disease, with devastating effects on patients' quality of life. This selective review will highlight major innovations and scientific discoveries in the areas of neuropathology, neuroimaging, diagnosis, and treatment that pertain to our understanding of the neuropsychological aspects of MS. Specifically, we focus on the recent discovery that MS produces pathogical lesions of gray matter (GM) that have consequences for cognitive functions. Methods for imaging these GM lesions in MS are discussed along with multimodal imaging studies that integrate structural and functional imaging methods to provide a better understanding of the relationship between cognitive test performance and functional reserve. Innovations in the screening and comprehensive assessment of cognitive disorders are presented along with recent research that examines cognitive dysfunction in pediatric MS. Results of innovative outcome studies in cognitive rehabilitation are discussed. Finally, we highlight trends for potential future innovations over the next decade. (JINS, 2017, 23, 832-842).
- Find related publications in this database (using NLM MeSH Indexing)
- Cognition Disorders - diagnosis
- Cognition Disorders - etiology
- History, 19th Century -
- History, 20th Century -
- History, 21st Century -
- Humans -
- Multiple Sclerosis - complications
- Multiple Sclerosis - history
- Multiple Sclerosis - psychology
- Neuroimaging -
- Neuropsychological Tests -
- Neuropsychology - history
- Neuropsychology - methods
- Find related publications in this database (Keywords)
- Multiple sclerosis
- Neuropsychology
- Cognition
- Neuropathology
- MRI
- Gray matter
- Rehabilitation