Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Görtz, M; Galli, U; Longerich, T; Zöller, M; Erb, U; Schemmer, P.
De novo synthesis of C4.4A in hepatocellular carcinoma promotes migration and invasion of tumor cells.
Oncol Rep. 2017; 38(5):2697-2704
Doi: 10.3892/or.2017.5980
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- Führende Autor*innen der Med Uni Graz
- Schemmer Peter
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- Abstract:
- C4.4A is a glycoprotein that is upregulated in several human malignancies, including colorectal, breast and renal cell carcinomas. Due to its highly restricted expression in healthy tissue, C4.4A was proposed as a potential diagnostic marker. Thus, the present study was designed to evaluate C4.4A expression and function in hepatocellular carcinoma (HCC) for the first time. Immunohistochemistry was performed to detect expression of C4.4A in human sections of healthy liver, primary HCC in the liver and metastatic HCC in the lung. To assess the contribution of C4.4A to HCC progression proliferation, apoptosis, migration and invasion assays were performed with C4.4A knockdown Huh7 and HepG2 cells. C4.4A is absent in healthy liver tissue. However, intense expression was seen in 59% of primary HCCs and strong expression in 80% of HCC lung metastases. C4.4A expression was also observed in human HCC cell lines, which strongly increased under hypoxic conditions. A C4.4A knock-down revealed that C4.4A is involved in both migration and invasion of HCC cells. Taken together, C4.4A expression in both primary and metastatic HCC suggests its potential value as a diagnostic marker for HCC. Due to its absence in healthy liver tissue, C4.4A might even serve as a possible therapeutic target, particularly for metastatic HCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Hepatocellular - metabolism
- Cell Adhesion Molecules - metabolism
- Cell Hypoxia -
- Cell Line, Tumor -
- Cell Movement -
- Disease Progression -
- GPI-Linked Proteins - metabolism
- Gene Expression Regulation, Neoplastic -
- Hep G2 Cells -
- Humans -
- Liver Neoplasms - metabolism
- Lung Neoplasms - metabolism
- Neoplasm Invasiveness -
- Up-Regulation -
- Find related publications in this database (Keywords)
- C4.4A
- hepatocellular carcinoma
- metastasis
- invasion
- hypoxia