Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Madreiter-Sokolowski, CT; Sokolowski, AA; Graier, WF.
Dosis Facit Sanitatem-Concentration-Dependent Effects of Resveratrol on Mitochondria.
Nutrients. 2017; 9(10):
Doi: 10.3390/nu9101117
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- Führende Autor*innen der Med Uni Graz
- Madreiter-Sokolowski Corina
- Co-Autor*innen der Med Uni Graz
- Graier Wolfgang
- Sokolowski Armin
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- Abstract:
- The naturally occurring polyphenol, resveratrol (RSV), is known for a broad range of actions. These include a positive impact on lifespan and health, but also pro-apoptotic anti-cancer properties. Interestingly, cell culture experiments have revealed a strong impact of RSV on mitochondrial function. The compound was demonstrated to affect mitochondrial respiration, structure and mass of mitochondria as well as mitochondrial membrane potential and, ultimately, mitochondria-associated cell death pathways. Notably, the mitochondrial effects of RSV show a very strict and remarkable concentration dependency: At low concentrations, RSV (<50 μM) fosters cellular antioxidant defense mechanisms, activates AMP-activated protein kinase (AMPK)- and sirtuin 1 (SIRT1)-linked pathways and enhances mitochondrial network formation. These mechanisms crucially contribute to the cytoprotective effects of RSV against toxins and disease-related damage, in vitro and in vivo. However, at higher concentrations, RSV (>50 μM) triggers changes in (sub-)cellular Ca2+ homeostasis, disruption of mitochondrial membrane potential and activation of caspases selectively yielding apoptotic cancer cell death, in vitro and in vivo. In this review, we discuss the promising therapeutic potential of RSV, which is most probably related to the compound's concentration-dependent manipulation of mitochondrial function and structure.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - pharmacology
- Antineoplastic Agents - toxicity
- Antioxidants - pharmacology
- Antioxidants - toxicity
- Apoptosis - drug effects
- Dose-Response Relationship, Drug -
- Energy Metabolism - drug effects
- Humans -
- Membrane Potential, Mitochondrial - drug effects
- Mitochondria - drug effects
- Mitochondria - metabolism
- Mitochondria - pathology
- Oxidative Stress - drug effects
- Resveratrol -
- Signal Transduction - drug effects
- Stilbenes - pharmacology
- Stilbenes - toxicity
- Find related publications in this database (Keywords)
- resveratrol
- mitochondria
- concentration-dependent effects
- cytotoxic agent
- cytoprotection