Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mörkl, S; Lackner, S; Müller, W; Gorkiewicz, G; Kashofer, K; Oberascher, A; Painold, A; Holl, A; Holzer, P; Meinitzer, A; Mangge, H; Holasek, S.
Gut microbiota and body composition in anorexia nervosa inpatients in comparison to athletes, overweight, obese, and normal weight controls.
Int J Eat Disord. 2017; 50(12):1421-1431
Doi: 10.1002/eat.22801
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leal Garcia Sabrina
- Co-Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
- Holasek Sandra Johanna
- Holl Anna
- Holzer Peter
- Kashofer Karl
- Lackner Sonja
- Mangge Harald
- Meinitzer Andreas
- Müller Wolfram
- Painold Annamaria
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- Abstract:
- Anorexia nervosa (AN) is a heterogeneous eating disorder associated with alterations of body structure and the gut microbiome. We aimed to investigate the gut microbiota composition of a large female cohort including different BMI groups and activity levels along with body composition parameters. 106 female participants were included in this cross-sectional study: AN patients (n = 18), athletes (n = 20), normal weight (n = 26), overweight (n = 22), and obese women (n = 20). DNA was extracted from stool samples and subjected to 16S rRNA gene analysis. The software Quantitative Insights Into Microbial Ecology (QIIME) was used to analyze data. Additionally, we performed anthropometric assessments, ultrasound measurements of subcutaneous adipose tissue thickness, bioimpedance analysis, administered depression inventories, and ascertained laboratory parameters and dietary intakes. Alpha diversity was particularly lower in AN patients and obese participants compared to other groups, while athletes showed highest alpha diversity. Several categories significantly associated with community structure were identified: body fat parameters, serum lipids, CRP, depression scales and smoking. Comparative analysis revealed Coriobacteriaceae as the only enriched phylotype in AN compared to other entities (LDA score >3.5). This study provides further evidence of intestinal dysbiosis in AN and sheds light on characteristics of the gut microbiome in different BMI and physical activity groups. These insights point to new modulation possibilities of the gut microbiota which could improve the standard therapy of AN. © 2017 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Anorexia Nervosa - microbiology
- Athletes - statistics & numerical data
- Body Composition - physiology
- Body Weight -
- Cross-Sectional Studies -
- Female -
- Gastrointestinal Microbiome - physiology
- Humans -
- Obesity - microbiology
- Overweight - microbiology
- Young Adult -
- Find related publications in this database (Keywords)
- anorexia nervosa
- athletes
- body composition
- body fat
- Coriobacteriaceae
- gut microbiome
- gut microbiota
- subcutaneous adipose tissue