Medizinische Universität Graz - Research portal
Selected Publication:
Tritthart, HA; Stark, U; Stark, G; Mahnert, W; Stender, CO; Schreibmayer, W.
Membrane actions of calcitonin gene-related peptide in cardiac and smooth muscle myocytes.
Ann N Y Acad Sci. 1992; 657(10):216-227
Doi: 10.1111/j.1749-6632.1992.tb22770.x
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Tritthart Helmut
- Co-authors Med Uni Graz
- Schreibmayer Wolfgang
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Calcitonin gene-related peptide is a 37-amino acid neuropeptide acting as a transmitter of nonadrenergic, noncholinergic nerves in the heart. Binding sites of high affinity have been reported in coronary arteries, in atria, and, of minor density, in ventricular myocardium. These sites are likely linked to G-proteins mediating modifications of ion channel opening probability and duration and to stimulation of adenylate cyclase activity and cAMP-mediated alterations of ion channel activities. In isolated and perfused guinea pig hearts, low concentrations of CGRP (1-3 nM) exerted no chronotropic effect, but increased coronary flow slightly. Atrioventricular conduction duration and effective refractory period of atrioventricular conduction were prolonged by 3 nM of CGRP. The higher concentration of 10 nM increased the sinus rate, and the effects on the atrioventricular node were counterbalanced. HV and QRS duration of the ECG remained essentially unchanged, but persistent ventricular fibrillation was inducible by burst stimulation in all CGRP-treated hearts. Results in human myometrial myocytes indicate that CGRP exerted direct G protein-mediated activation of potassium channels, leading to hyperpolarization and smooth muscle relaxation. Activation of potassium channels, most prominent in smooth muscle relaxation, is likely an additional factor in the cardiostimulatory profile of CGRP.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - drug effects
- Animals - drug effects
- Calcitonin Gene-Related Peptide - pharmacology
- Cell Membrane - drug effects
- Electric Stimulation - drug effects
- Female - drug effects
- Guinea Pigs - drug effects
- Heart - drug effects
- Heart Conduction System - drug effects
- Heart Rate - drug effects
- Isoproterenol - pharmacology
- Male - pharmacology
- Muscle, Smooth - drug effects