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Hay, JC; Chao, DS; Kuo, CS; Scheller, RH.
Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Cell. 1997; 89(1):149-158 Doi: 10.1016/S0092-8674(00)80191-9
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Leading authors Med Uni Graz: Hay Jesse
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Abstract:: The proposed cis-Golgi vesicle receptor syntaxin 5 was found in a complex with Golgi-associated SNARE of 28 kDa (GOS-28), rbet1, rsly1, and two novel proteins characterized herein: rat sec22b and membrin, both cytoplasmically oriented integral membrane proteins. The complex appears to recapitulate vesicle docking interactions of proteins originating from distinct compartments, since syntaxin 5, rbet1, and GOS-28 localize to Golgi membranes, whereas mouse sec22b and membrin accumulate in the endoplasmic reticulum. Protein interactions in the complex are dramatically rearranged by N-ethylmaleimide-sensitive factor. The complex consists of two or more subcomplexes with some members (rat sec22b and syntaxin 5) in common and others (rbet1 and GOS-28) mutually exclusively associated. We propose that these protein interactions determine vesicle docking/fusion fidelity between the endoplasmic reticulum and Golgi.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Biological Transport - physiology; COS Cells - physiology; Carrier Proteins - physiology; Detergents -; Endoplasmic Reticulum - chemistry; Endoplasmic Reticulum - metabolism; Epitopes - analysis; Gene Expression - physiology; Golgi Apparatus - chemistry; Golgi Apparatus - metabolism; Mammals -; Membrane Proteins - analysis; Membrane Proteins - genetics; Membrane Proteins - isolation & purification; Membrane Proteins - physiology; Mice -; Molecular Sequence Data -; N-Ethylmaleimide-Sensitive Proteins -; Nerve Tissue Proteins - analysis; Nerve Tissue Proteins - isolation & purification; Neurons - cytology; Neurons - metabolism; Qa-SNARE Proteins -; Qb-SNARE Proteins -; Qc-SNARE Proteins -; R-SNARE Proteins -; Rabbits -; Rats -; Rats, Sprague-Dawley -; Sequence Homology, Amino Acid -; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins -; Subcellular Fractions - chemistry; Synaptic Vesicles - chemistry; Synaptic Vesicles - metabolism; Vesicular Transport Proteins -