Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hay, JC; Chao, DS; Kuo, CS; Scheller, RH.
Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Cell. 1997; 89(1):149-158
Doi: 10.1016/S0092-8674(00)80191-9
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- Führende Autor*innen der Med Uni Graz
- Hay Jesse
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- Abstract:
- The proposed cis-Golgi vesicle receptor syntaxin 5 was found in a complex with Golgi-associated SNARE of 28 kDa (GOS-28), rbet1, rsly1, and two novel proteins characterized herein: rat sec22b and membrin, both cytoplasmically oriented integral membrane proteins. The complex appears to recapitulate vesicle docking interactions of proteins originating from distinct compartments, since syntaxin 5, rbet1, and GOS-28 localize to Golgi membranes, whereas mouse sec22b and membrin accumulate in the endoplasmic reticulum. Protein interactions in the complex are dramatically rearranged by N-ethylmaleimide-sensitive factor. The complex consists of two or more subcomplexes with some members (rat sec22b and syntaxin 5) in common and others (rbet1 and GOS-28) mutually exclusively associated. We propose that these protein interactions determine vesicle docking/fusion fidelity between the endoplasmic reticulum and Golgi.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biological Transport - physiology
- COS Cells - physiology
- Carrier Proteins - physiology
- Detergents -
- Endoplasmic Reticulum - chemistry
- Endoplasmic Reticulum - metabolism
- Epitopes - analysis
- Gene Expression - physiology
- Golgi Apparatus - chemistry
- Golgi Apparatus - metabolism
- Mammals -
- Membrane Proteins - analysis
- Membrane Proteins - genetics
- Membrane Proteins - isolation & purification
- Membrane Proteins - physiology
- Mice -
- Molecular Sequence Data -
- N-Ethylmaleimide-Sensitive Proteins -
- Nerve Tissue Proteins - analysis
- Nerve Tissue Proteins - isolation & purification
- Neurons - cytology
- Neurons - metabolism
- Qa-SNARE Proteins -
- Qb-SNARE Proteins -
- Qc-SNARE Proteins -
- R-SNARE Proteins -
- Rabbits -
- Rats -
- Rats, Sprague-Dawley -
- Sequence Homology, Amino Acid -
- Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins -
- Subcellular Fractions - chemistry
- Synaptic Vesicles - chemistry
- Synaptic Vesicles - metabolism
- Vesicular Transport Proteins -