Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trahey, M; Oh, HS; Cameron, CE; Hay, JC.
Poliovirus infection transiently increases COPII vesicle budding.
J Virol. 2012; 86(18):9675-9682
Doi: 10.1128/JVI.01159-12
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- Führende Autor*innen der Med Uni Graz
- Hay Jesse
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- Abstract:
- Poliovirus (PV) requires membranes of the host cell's secretory pathway to generate replication complexes (RCs) for viral RNA synthesis. Recent work identified the intermediate compartment and the Golgi apparatus as the precursors of the replication "organelles" of PV (N. Y. Hsu et al., Cell 141:799-811, 2010). In this study, we examined the effect of PV on COPII vesicles, the secretory cargo carriers that bud from the endoplasmic reticulum and homotypically fuse to form the intermediate compartment that matures into the Golgi apparatus. We found that infection by PV results in a biphasic change in functional COPII vesicle biogenesis in cells, with an early enhancement and subsequent inhibition. Concomitant with the early increase in COPII vesicle formation, we found an increase in the membrane fraction of Sec16A, a key regulator of COPII vesicle formation. We suggest that the early burst in COPII vesicle formation detected benefits PV by increasing the precursor pool required for the formation of its RCs.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- COP-Coated Vesicles - physiology
- COP-Coated Vesicles - ultrastructure
- COP-Coated Vesicles - virology
- Cell Line -
- HeLa Cells -
- Host-Pathogen Interactions - physiology
- Humans -
- Membrane Fusion - physiology
- Microscopy, Electron, Transmission -
- Poliomyelitis - pathology
- Poliomyelitis - physiopathology
- Poliomyelitis - virology
- Poliovirus - pathogenicity
- Poliovirus - physiology
- Rats -
- Receptors, Virus - physiology
- Vesicular Transport Proteins - physiology