Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hauer, AC.
Unconjugated hyperbilirubinemia. Laboratory and clinical differential diagnostics
MONATSSCHR KINDERH. 2017; 165(10): 907-921.
Doi: 10.1007/s00112-017-0292-2
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- Hauer Almuthe
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- Abstract:
- Unconjugated hyperbilirubinemia is characterised by an increased total serum bilirubin, with a direct bilirubin of < 15%. Jaundice of pre- or intrahepatic origin is the main clinical symptom. The most dangerous complication is bilirubin encephalopathy (kernicterus), particularly in neonates. Thus, it is essential to differentiate between the more frequent physiological and the much rarer pathological jaundice in order to initiate treatment in a timely manner. A stepwise screening guided by results is recommended: This includes systematic transcutaneous/invasive bilirubin measurements, assessment of measured values using age-related nomograms and differentiated diagnostics in a time-dependent correlation with the indirect hyperbilirubinemia's onset. Genetically determined disorders of bilirubin metabolism with varied degrees of severity (Gilbert disease; Crigler-Najjar syndrome I, II) also present initially with unconjugated hyperbilirubinemia.
- Find related publications in this database (Keywords)
- Bilirubin
- (Neonatal) jaundice
- Meulengracht syndrome
- Crigler-Najjar syndrome
- Phototherapy