Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Dejaco, C; Brouwer, E; Mason, JC; Buttgereit, F; Matteson, EL; Dasgupta, B.
Giant cell arteritis and polymyalgia rheumatica: current challenges and opportunities.
NAT REV RHEUMATOL. 2017; 13(10): 578-592.
Doi: 10.1038/nrrheum.2017.142
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- Führende Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- The fields of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) have advanced rapidly, resulting in a new understanding of these diseases. Fast-track strategies and improved awareness programmes that prevent irreversible sight loss through early diagnosis and treatment are a notable advance. Ultrasonography and other imaging techniques have been introduced into routine clinical practice and there have been promising reports on the efficacy of biologic agents, particularly IL-6 antagonists such as tocilizumab, in treating these conditions. Along with these developments, which should improve outcomes in patients with GCA and PMR, new questions and unmet needs have emerged; future research should address which pathogenetic mechanisms contribute to the different phases and clinical phenotypes of GCA, what role imaging has in the early diagnosis and monitoring of GCA and PMR, and in which patients and phases of these diseases novel biologic drugs should be used. This article discusses the implications of recent developments in our understanding of GCA and PMR, as well as the unmet needs concerning epidemiology, pathogenesis, imaging and treatment of these diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal, Humanized - therapeutic use
- Clinical Trials as Topic -
- Early Diagnosis -
- Giant Cell Arteritis - diagnostic imaging
- Giant Cell Arteritis - drug therapy
- Giant Cell Arteritis - epidemiology
- Humans -
- Polymyalgia Rheumatica - diagnostic imaging
- Polymyalgia Rheumatica - drug therapy
- Polymyalgia Rheumatica - epidemiology