Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Neumayer, B; Amerstorfer, E; Diwoky, C; Lindtner, RA; Wadl, E; Scheurer, E; Weinberg, AM; Stollberger, R.
Assessment of pharmacokinetics for microvessel proliferation by DCE-MRI for early detection of physeal bone bridge formation in an animal model.
MAGMA. 2017; 30(5):417-427
Doi: 10.1007/s10334-017-0615-2
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- Führende Autor*innen der Med Uni Graz
- Neumayer Bernhard
- Stollberger Rudolf
- Co-Autor*innen der Med Uni Graz
- Amerstorfer Eva
- Diwoky Clemens
- Scheurer Eva
- Weinberg Annelie-Martina
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- Abstract:
- Bone bridge formation occurs after physeal lesions and can lead to growth arrest if not reversed. Previous investigations on the underlying mechanisms of this formation used histological methods. Therefore, this study aimed to apply a minimally invasive method using dynamic contrast-enhanced MRI (DCE-MRI). Changes in functional parameters related to the microvessel system were assessed in a longitudinal study of a cohort of an animal model applying a reference region model. The development of morphology of the injured physis was investigated with 3D high-resolution MRI. To acquire complementary information for MRI-related findings qRT-PCR and immunohistochemical data were acquired for a second cohort of the animal model. The evaluation of the pharmacokinetic parameters showed a first rise of the transfer coefficient 7 days post-lesion and a maximum 42 days after operation. The analysis of the complementary data showed a connection of the first rise to microvessel proliferation while the maximum value was linked to bone remodeling. The pharmacokinetic analysis of DCE-MRI provides information on a proliferation of microvessels during the healing process as a sign for bone bridge formation. Thereby, DCE-MRI could identify details, which up to now required analyses of highly invasive methods.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Collagen Type IV - metabolism
- Contrast Media -
- Gadolinium -
- Growth Plate - blood supply
- Growth Plate - diagnostic imaging
- Growth Plate - metabolism
- Imaging, Three-Dimensional -
- Immunohistochemistry -
- Longitudinal Studies -
- Magnetic Resonance Imaging - methods
- Male -
- Microvessels - diagnostic imaging
- Microvessels - growth & development
- Microvessels - metabolism
- Organometallic Compounds -
- Rats -
- Rats, Sprague-Dawley -
- Real-Time Polymerase Chain Reaction -
- Find related publications in this database (Keywords)
- Contrast agents
- Animal model
- Physis