Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Salzer, HJF; Lange, C; Hönigl, M.
[Aspergillus in airway material : Ignore or treat?]
Internist (Berl). 2017; 58(11):1150-1162
Doi: 10.1007/s00108-017-0334-9
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Hönigl Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Fungi of the genus Aspergillus are ubiquitously present. Even though humans inhale Aspergillus spores daily under natural conditions, Aspergillus-associated pulmonary diseases only occur under special circumstances. Whether an Aspergillus-associated disease develops and which type of Aspergillus-associated disease develops depends on the constitution of the host. The spectrum of Aspergillus-associated pulmonary diseases ranges from allergic diseases, such as hypersensitivity pneumonitis to allergic infectious diseases, such as allergic bronchopulmonary aspergillosis (ABPA) and bronchocentric granulomatosis (BG) to infectious diseases, such as invasive (IA) or semi-invasive aspergillosis (SIA) and chronic pulmonary aspergillosis (CPA). Identification of Aspergillus spp. from sputum or bronchopulmonary secretions is not sufficient for a definitive diagnosis of Aspergillus-associated infections. The gold standard is the identification of Aspergillus spp. from lung tissue by culture or by histopathological methods; however, in clinical practice the decision to initiate antifungal therapy is more often based on immunological methods, such as the detection of Aspergillus-specific IgG antibodies from peripheral blood or galactomannan antigens from bronchoalveolar lavages. Acute IA or SIA infections have a high mortality and require immediate antifungal therapy. With rare exceptions CPA cannot be cured by medicinal therapy alone; however, active CPA can be brought into remission with antifungal therapy. Eradication of Aspergillus in CPA can as a rule only be successful using a combined antimycotic and surgical intervention.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Fungal - blood
- Antifungal Agents - therapeutic use
- Aspergillosis - diagnosis
- Aspergillosis - drug therapy
- Aspergillosis - immunology
- Aspergillosis - microbiology
- Aspergillus - immunology
- Aspergillus - isolation & purification
- Aspergillus - pathogenicity
- Bronchoalveolar Lavage Fluid - immunology
- Humans -
- Immunoglobulin G - blood
- Invasive Pulmonary Aspergillosis - diagnosis
- Invasive Pulmonary Aspergillosis - drug therapy
- Invasive Pulmonary Aspergillosis - immunology
- Invasive Pulmonary Aspergillosis - microbiology
- Lung - microbiology
- Lung Diseases, Fungal - diagnosis
- Lung Diseases, Fungal - immunology
- Lung Diseases, Fungal - microbiology
- Mannans - analysis
- Respiratory System - immunology
- Respiratory System - microbiology
- Virulence -