Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Heinemann, A; Jocic, M; Holzer-Petsche, U; Pethö, G; Peskar, BM; Horwell, DC; Holzer, P.
Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa.
BRIT J PHARMACOL. 1995; 116: 2274-2278.
Doi: 10.1111/j.1476-5381.1995.tb15064.x
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- Führende Autor*innen der Med Uni Graz
- Heinemann Akos
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Holzer Ulrike
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- Abstract:
- 1. Cholecystokinin octapeptide (CCK-8) and gastrin-17 augment gastric mucosal blood flow in the rat. The present study examined whether the gastric vasodilator effect of these peptides is mediated by CCKA or CCKB receptors. 2. Intravenous injection of CAM-1481 (1 mg kg-1), a dipeptoid antagonist of CCKA receptors, or CAM-1028, a dipeptoid CCKB receptor antagonist (1 mg kg-1), had no effect on basal gastric mucosal blood flow as determined by the clearance of hydrogen in urethane-anaesthetized rats. 3. Intravenous infusion of CCK-8 or gastrin-17 (8-200 pmol min-1) increased gastric mucosal blood flow in a dose-dependent fashion. The CCKB receptor antagonist, CAM-1028, significantly attenuated the hyperaemic response to CCK-8 and gastrin-17 whereas the CCKA receptor antagonist, CAM-1481, did not antagonize CCK-8 but caused a slight attenuation of the vasodilator response to gastrin-17. 4. The selectivity of the two antagonists was proved by the findings that CAM-1028, but not CAM-1481, inhibited gastric acid secretion evoked by CCK-8 or gastrin-17 (CCKB receptor assay) while CAM-1481, but not CAM-1028, inhibited the CCK-8-induced contraction of guinea-pig isolated gall bladder strips (CCKA receptor assay). 5. These data show that the actions of CCK-8 and gastrin-17 to increase mucosal blood flow in the rat stomach are primarily mediated by CCKB receptors.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cholecystokinin - pharmacology
- Dipeptides - pharmacology
- Female - pharmacology
- Gallbladder - drug effects
- Gastric Acidity Determination - drug effects
- Gastric Mucosa - blood supply
- Gastrins - pharmacology
- Guinea Pigs - pharmacology
- Hyperemia - physiopathology
- In Vitro - physiopathology
- Indoles - pharmacology
- Meglumine - analogs and derivatives
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Rats - drug effects
- Rats, Sprague-Dawley - drug effects
- Receptors, Cholecystokinin - antagonists and inhibitors
- Regional Blood Flow - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Cholecystokinin (CCK)
- Cholecystokinin Octapeptide (CCK-8)
- Gastrin
- Gastrin-17
- CCK Receptors
- Ccka Receptors
- Cckb Receptors
- CCK Receptor Antagonists
- CAM-1028
- CAM-1481
- Gastric Mucosal Blood Flow
- Vasodilatation
- Hyperemia
- Gastric Acid Secretion
- Ga