Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sarny, S; Neumayer, M; Kofler, J; El-Shabrawi, Y.
Ocular toxicity due to Trametinib and Dabrafenib.
BMC Ophthalmol. 2017; 17(1):146-146
Doi: 10.1186/s12886-017-0541-0
(- Case Report)
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- Leading authors Med Uni Graz
- Sarny Stephanie
- Co-authors Med Uni Graz
- El-Shabrawi Yosuf
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- Abstract:
- To report a case of uveitis and neuroretinal detachment in a patient treated with Trametinib and Dabrafenib due to metastatic cutaneous melanoma stage IV. We evaluated slit lamp examination, fundoscopy, optical coherence tomography, fluorescein and indocyanine green angiography in a 66 years old man suffering visual loss. Fundoscopy showed serous neuroretinal detachment of the fovea accompanied with white spots surrounding the fovea in both eyes. Although therapy with Trametinib and Dabrafenib was stopped uveitis anterior was seen 2 weeks later. After a year, the therapy was started again and the serous neuroretinal detachment appeared once more, however without inflammatory reaction of the anterior chamber. Patients treated with Trametinib and Dabrafenib should undergo consecutive eye examinations from the beginning of the therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antineoplastic Agents - adverse effects
- Humans -
- Imidazoles - adverse effects
- Male -
- Oximes - adverse effects
- Protein Kinase Inhibitors - adverse effects
- Pyridones - adverse effects
- Pyrimidinones - adverse effects
- Retinal Detachment - chemically induced
- Uveitis - chemically induced
- Find related publications in this database (Keywords)
- Trametinib
- Dabrafenib
- Ocular toxicity
- Neuroretinal detachment
- Uveitis anterior