Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Heldt, S; Eigl, S; Prattes, J; Flick, H; Rabensteiner, J; Prüller, F; Niedrist, T; Neumeister, P; Wölfler, A; Strohmaier, H; Krause, R; Hoenigl, M.
Levels of interleukin (IL)-6 and IL-8 are elevated in serum and bronchoalveolar lavage fluid of haematological patients with invasive pulmonary aspergillosis.
Mycoses. 2017; 60(12):818-825
Doi: 10.1111/myc.12679
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- Führende Autor*innen der Med Uni Graz
- Heldt Sven
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Eigl Susanne
- Flick Holger
- Krause Robert
- Neumeister Peter
- Niedrist Tobias Josef
- Prattes Jürgen
- Prüller Florian
- Rabensteiner Jasmin
- Strohmaier Heimo
- Wölfler Albert
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- Abstract:
- Aspergillus spp. have been shown to induce T-helper cell (Th) 1 and Th17 subsets resulting in elevated levels of several cytokines. The objective of this study was to analyse a bundle of cytokines in serum and bronchoalveolar lavage fluid (BALF) in patients with and without invasive pulmonary aspergillosis (IPA). This nested case-control analysis included 10 patients with probable/proven IPA and 20 matched controls without evidence of IPA, out of a pool of prospectively enrolled (2014-2017) adult cases with underlying haematological malignancies and suspected pulmonary infection. Serum samples were collected within 24 hours of BALF sampling. All samples were stored at -70°C for retrospective determination of cytokines. IL-6 and IL-8 were significantly associated with IPA in both serum (P = .011 and P = .028) and BALF (P = .006 and P = .012, respectively), and a trend was observed for serum IL-10 (P = .059). In multivariate conditional logistic regression analysis, IL-10 remained a significant predictor of IPA in serum and IL-8 among BALF cytokines. In conclusion, levels of IL-6 and IL-8 were significantly associated with probable/proven IPA, and a similar trend was observed for serum IL-10. Future cohort studies should determine the diagnostic potential of these cytokines for IPA, and evaluate combinations with other IPA biomarkers/diagnostic tests. © 2017 Blackwell Verlag GmbH.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biomarkers - analysis
- Biomarkers - blood
- Bronchoalveolar Lavage Fluid - chemistry
- Female -
- Hematologic Diseases - complications
- Humans -
- Interleukin-6 - analysis
- Interleukin-6 - blood
- Interleukin-8 - analysis
- Interleukin-8 - blood
- Invasive Pulmonary Aspergillosis - blood
- Invasive Pulmonary Aspergillosis - diagnosis
- Invasive Pulmonary Aspergillosis - etiology
- Male -
- Middle Aged -
- Retrospective Studies -
- Find related publications in this database (Keywords)
- Aspergillus
- BAL
- haematological malignancy
- IFN-
- IL-10
- IL-17A
- serum