Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stana, J; Stergar, J; Gradišnik, L; Flis, V; Kargl, R; Fröhlich, E; Stana Kleinschek, K; Mohan, T; Maver, U.
Multilayered Polysaccharide Nanofilms for Controlled Delivery of Pentoxifylline and Possible Treatment of Chronic Venous Ulceration.
Biomacromolecules. 2017; 18(9):2732-2746
Doi: 10.1021/acs.biomac.7b00523
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Local drug delivery systems made from nontoxic polysaccharide nanofilms have an enormous potential in wound care. A detailed understanding of the structural, surface, physicochemical, and cytotoxic properties of such systems is crucial to design clinically efficacious materials. Herein, we fabricated polysaccharide-based nanofilms onto either a 2D model (SiO2 and Au sensors) or on nonwoven alginate 3D substrates using an alternating assembly of N,N,N-trimethylchitosan (TMC) and alginic acid (ALG) by a spin-assisted layer-by-layer (LbL) technique. These TMC/ALG multilayered nanofilms are used for a uniform encapsulation and controlled release of pentoxifylline (PTX), a potent anti-inflammatory drug for treatment of the chronic venous ulceration. We show a tailorable film growth and mass, morphology, as well as surface properties (charge, hydrophilicity, porosity) of the assembled nanofilms through control of the coating during the spin-assisted assembly. The uniform distribution of the encapsulated PTX in the TMC/ALG nanofilms is preserved even with when the amount of the incorporated PTX increases. The PTX release mechanism from the model and real systems is studied in detail and is very comparable for both systems. Finally, different cell-based assays illustrated the potential of the TMC/ALG multilayer system in wound care (e.g., treatment chronic venous ulceration) applications, including a decrease of TNF-α secretion, a common indicator of inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Alginates - chemistry
- Cell Line -
- Chitosan - chemistry
- Humans -
- Nanostructures - chemistry
- Pentoxifylline - administration & dosage
- Platelet Aggregation Inhibitors - administration & dosage
- Varicose Ulcer - drug therapy