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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Enko, D; Wagner, H; Kriegshäuser, G; Brandmayr, W; Halwachs-Baumann, G; Schnedl, WJ; Zelzer, S; Mangge, H; Meinitzer, A.
Assessment of tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption.
Psychiatry Res. 2018; 262(1):595-599
Doi: 10.1016/j.psychres.2017.09.049
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Enko Dietmar
- Co-authors Med Uni Graz
- Baumann Gabriele
- Kriegshäuser Gernot
- Mangge Harald
- Meinitzer Andreas
- Schnedl Wolfgang
- Zelzer Sieglinde
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- Abstract:
- This prospective cross-sectional study aimed to investigate the potential association between primary-adult lactose malabsorption, fructose malabsorption, tryptophan (TRP) metabolism and the presence of depressive signs. Overall 251 patients, who were referred for lactase gene C/T-13910 polymorphism genotyping and fructose hydrogen/methane breath testing, were included. All participants filled out the Beck Depression Inventory (BDI II). Serum concentrations of tryptophan (TRP), kynurenine (KYN), kynuric acid (KYNA), and TRP competing amino acids (leucine, isoleucine, valine, phenylalanine, tyrosine) were measured by high-pressure liquid-chromatography. Logistic regression analysis was performed with lactose malabsorption, fructose malabsorption and all potential biomarkers of TRP metabolism to assess the effect on signs of depression, defined as a BDI II score > 13. Primary-adult lactose malabsorption and fructose malabsorption was detected in 65 (25.90%) and 65 (25.90%) patients, respectively. Fructose malabsorption was significantly associated with BDI II score, whereas no such relationship was found for lactose malabsorption. Serum levels of TRP and TRP metabolites were no predictors of depression. The authors suggest to conduct further prospective longitudinal studies in order to get further insight of associations between carbohydrate malabsorption, biomarkers and mood disorders. Copyright © 2017 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers - blood
- Breath Tests -
- Cross-Sectional Studies -
- Depression - blood
- Depression - etiology
- Female -
- Fructose - blood
- Fructose Intolerance - blood
- Fructose Intolerance - psychology
- Humans -
- Kynurenine - blood
- Lactase - blood
- Lactase - deficiency
- Lactose Intolerance - blood
- Lactose Intolerance - psychology
- Logistic Models -
- Male -
- Middle Aged -
- Prospective Studies -
- Psychiatric Status Rating Scales -
- Tryptophan - blood
- Find related publications in this database (Keywords)
- Depression
- Carbohydrates
- Metabolism
- Tryptophan