Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P.
Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366
Doi: 10.1016/j.bbadis.2017.08.028
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fickert Peter
- Tatscher Elisabeth
- Co-Autor*innen der Med Uni Graz
- Pollheimer Marion
- Rosenkranz Alexander
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Acute kidney injury is common in patients with liver disease and associated with significant morbidity and mortality. Besides bacterial infections, fluid loss, and use of nephrotoxic drugs AKI in liver disease may be triggered by tubular toxicity of cholephiles. Cholemic nephropathy, also known as bile cast nephropathy, supposedly represents a widely underestimated but important cause of renal dysfunction in cholestasic or advanced liver diseases with jaundice. Cholemic nephropathy describes impaired renal function along with characteristic histomorphological changes consisting of intratubular cast formation and tubular epithelial cell injury directed towards distal nephron segments. The underlying pathophysiologic mechanisms are not entirely understood and clear defined diagnostic criteria are still missing. This review aims to summarize (i) the present knowledge on clinical and morphological characteristics of cholemic nephropathy, (ii) available preclinical models, (iii) potential pathomechanisms especially the potential role of bile acids, and (iv) future diagnostic and therapeutic strategies for cholemic nephropathy. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen. Copyright © 2017 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Kidney Injury - diagnosis
- Acute Kidney Injury - drug therapy
- Acute Kidney Injury - etiology
- Acute Kidney Injury - pathology
- Animals -
- Bile Acids and Salts - metabolism
- Bile Acids and Salts - toxicity
- Bile Ducts - cytology
- Bile Ducts - drug effects
- Bile Ducts - metabolism
- Bile Ducts - pathology
- Bilirubin - metabolism
- Bilirubin - toxicity
- Cholagogues and Choleretics - pharmacology
- Cholagogues and Choleretics - therapeutic use
- Cholestasis - complications
- Cholestasis - drug therapy
- Cholestasis - pathology
- Disease Models, Animal -
- Epithelial Cells - drug effects
- Epithelial Cells - metabolism
- Hepatocytes - drug effects
- Hepatocytes - metabolism
- Humans -
- Jaundice, Obstructive - complications
- Jaundice, Obstructive - drug therapy
- Jaundice, Obstructive - pathology
- Kidney Tubules - pathology
- Liver - cytology
- Liver - drug effects
- Liver - metabolism
- Liver - pathology
- Renal Elimination -
- Ursodeoxycholic Acid - analogs & derivatives
- Ursodeoxycholic Acid - pharmacology
- Ursodeoxycholic Acid - therapeutic use
- Find related publications in this database (Keywords)
- Cholemic nephropathy
- Bile cast nephropathy
- Bile acids
- Liver cirrhosis
- Acute kidney injury