Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fahrner, M; Schindl, R; Muik, M; Derler, I; Romanin, C.
The STIM-Orai Pathway: The Interactions Between STIM and Orai.
Adv Exp Med Biol. 2017; 993(14-15):59-81
Doi: 10.1007/978-3-319-57732-6_4
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- Co-Autor*innen der Med Uni Graz
- Schindl Rainer
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- Abstract:
- A primary Ca2+ entry pathway in non-excitable cells is established by the Ca2+ release-activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane. STIM1 senses the luminal Ca2+ content, and store depletion induces its oligomerization into puncta-like structures, thereby triggering coupling to as well as activation of Orai channels. A C-terminal STIM1 domain is assumed to couple to both C- and N-terminal, cytosolic strands of Orai, accomplishing gating of the channel. Here we highlight the inter- and intramolecular steps of the STIM1-Orai signaling cascade together with critical sites of the pore structure that accomplishes Ca2+ permeation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Calcium Release Activated Calcium Channels - metabolism
- Calcium Signaling - physiology
- Cell Membrane - metabolism
- Humans -
- Stromal Interaction Molecule 1 - metabolism
- Find related publications in this database (Keywords)
- STIM-Orai coupling
- STIM oligomerization
- Orai nexus
- Orai activation
- Orai pore