Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szurian, K; Till, H; Amerstorfer, E; Hinteregger, N; Mischinger, HJ; Liegl-Atzwanger, B; Brcic, I.
Rarity among benign gastric tumors: Plexiform fibromyxoma - Report of two cases.
World J Gastroenterol. 2017; 23(31):5817-5822
Doi: 10.3748/wjg.v23.i31.5817
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Brcic Iva
- Szurian Kinga
- Co-Autor*innen der Med Uni Graz
- Amerstorfer Eva
- Liegl-Atzwanger Bernadette
- Mischinger Hans-Jörg
- Stranner Nicole
- Till Holger
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- Abstract:
- Plexiform fibromyxoma is a very rare mesenchymal tumor of the stomach, found almost exclusively in the antrum/pylorus region. The most common presenting symptoms are anemia, hematemesis, nausea and unintentional weight loss, without sex or age predilection. We describe here two cases of plexiform fibromyxoma, involving a 16-year-old female and a 34-year-old male. Both patients underwent complete resection (R0) by distal gastrectomy and retrocolic gastrojejunostomy (according to Billroth 2); for both, the postoperative course was uneventful. Histology showed multiple intramural and subserosal nodules with characteristic plexiform growth, featuring bland spindle cells situated in an abundant myxoid stroma with low mitotic activity. Immunohistochemistry showed α-smooth muscle actin-positive spindle cells, focal positivity for CD10, and negative staining for KIT, DOG1, CD34, S100, β-catenin, STAT-6 and anaplastic lymphoma kinase. One of the cases showed focal positivity for h-caldesmon and desmin. Upon follow-up, no sign of disease was found. In the differential diagnosis of plexiform fibromyxoma, it is important to exclude the more common gastrointestinal stromal tumors as they have greater potential for aggressive behavior. Other lesions, like neuronal and vascular tumors, inflammatory fibroid polyps, abdominal desmoid-type fibromatosis, solitary fibrous tumors and smooth muscle tumors, must also be excluded.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Anoctamin-1 - metabolism
- Biomarkers, Tumor - metabolism
- Calmodulin-Binding Proteins - metabolism
- Diagnosis, Differential -
- Female -
- Fibroma - diagnosis
- Fibroma - pathology
- Fibroma - surgery
- Gastrectomy -
- Gastric Bypass -
- Gastrointestinal Stromal Tumors - diagnosis
- Gastrointestinal Stromal Tumors - pathology
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Neoplasm Proteins - metabolism
- Positron Emission Tomography Computed Tomography -
- Proto-Oncogene Proteins c-kit - metabolism
- Stomach - pathology
- Stomach - surgery
- Stomach Neoplasms - diagnosis
- Stomach Neoplasms - pathology
- Stomach Neoplasms - surgery
- Find related publications in this database (Keywords)
- Plexiform fibromyxoma
- Plexiform angiomyxoid myofibroblastic tumor
- Gastrointestinal stromal tumor
- Stomach
- Benign gastric tumor