Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Foschini, MP; Miglio, R; Quinn, C; Belgio, B; Regitnig, P; Bianchi, S; Nannini, R; Buerger, H; Kaya, H; Illyés, I; Kulka, J; Wells, CA; De Gaetano, J; Lipeniece-Karele, I; Cserni, G.
Prognostic impact of macrometastasis linear size in sentinel node biopsy for breast carcinoma.
Eur J Surg Oncol. 2017; 43(8):1421-1427
Doi: 10.1016/j.ejso.2017.05.007
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- Co-Autor*innen der Med Uni Graz
- Regitnig Peter
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- Abstract:
- The aim of the present study was to evaluate the risk of axillary non-sentinel lymph-node metastases (ALN) in breast cancer patients presenting macrometastasis (Mac-m) in the sentinel lymph node (SN). A retrospective series of 1464 breast cancers from patients who underwent ALN dissection following the diagnosis of Mac-m in the sentinel node (SN) was studied. In all the cases the MAC-m linear size was evaluated and correlated with presence or absence of non-SN ALN metastases. Non-SN metastases were detected in 644∖1464 cases (43.98%). The risk of further axillary metastases ranged from 20.2% (37/183) in cases with Mac-m between 2 and 2.9 mm, to 65.3% (262/401) in cases with Mac-m measuring > 10 mm. The risk of non-SN ALN metastases showed a 3% increase, parallel to each mm increment in SN metastasis size. The data evaluated with the receiver operating characteristic (ROC) curve showed that the Mac-m could be subdivided according to a new cut-off of 7 mm. pT1 tumours, with Mac-m < 7 mm had a risk of non-SN ALN metastases of <30%. Furthermore 109/127 of these (85.8%) had 3 or less non-SN ALN -metastases. The present data give a detailed description on the risk of non-SN ALN involvement, that may be useful in the evaluation of breast cancer patients. It is suggested that a Mac-m size of <7 mm is related to a low residual axillary disease burden in breast cancer patients with small (pT1) tumours. Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Axilla -
- Breast Neoplasms - pathology
- Female -
- Humans -
- Lymphatic Metastasis - pathology
- Middle Aged -
- Neoplasm Staging -
- Prognosis -
- Retrospective Studies -
- Sentinel Lymph Node Biopsy -
- Find related publications in this database (Keywords)
- Sentinel node
- Macrometastasis
- Breast cancer
- Axillary dissection
- Axillary metastasis
- Staging