Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, G; Pux, C; Babeluk, R; Hermann, B; Stoiser, E; De Campo, A; Grisold, A; Zollner-Schwetz, I; Krause, R; Schippinger, W.
MRSA prevalence rates detected in a tertiary care hospital in Austria and successful treatment of MRSA positive patients applying a decontamination regime with octenidine.
Eur J Clin Microbiol Infect Dis. 2018; 37(1):21-27
Doi: 10.1007/s10096-017-3095-4
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- Co-Autor*innen der Med Uni Graz
- DeCampo Antonella
- Grisold Andrea
- Krause Robert
- Zollner-Schwetz Ines
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- Abstract:
- Methicillin-resistant Staphylococcus aureus (MRSA) decontamination regimens predominantly use chlorhexidine bathing in combination with mupirocin nasal ointment. However, resistances in Staphylococcus aureus strains are increasingly common and there is a need of alternative, safe and feasible protocols. This interventional cohort study performed at the Albert Schweitzer Hospital in Graz, Austria, aimed to (1) determine MRSA prevalence at different body sites and (2) assess the efficacy of the decontamination using octenidine-based leave-on products added to existing robust infection control measures. All inpatients of this tertiary care hospital being treated in geriatric medical wards (GWs) and apallic care units (ACUs) were screened for MRSA and decontamination rates were determined after one, two or three decontamination cycles, respectively. At baseline, MRSA was detected in 25 of the 126 patients screened (19.8%). We found MRSA in 13/126 (10.3%) swabs from nasal vestibules, in 12/126 (9.5%) skin swabs, in 11/51 (21.6%) swabs from PEG-stomata or suprapubic catheters and in 8/13 (61.5%) tracheostomata swabs. A maximum of three 5-day decontamination cycles reduced the number of MRSA positive patients by 68.0%. Excluding non-compliant and deceased patients, decontamination reduced MRSA carriage by 93.3% (n = 15). No adverse events related to the applied decontamination regimen occurred. Exclusive screening of the nose might underreport MRSA prevalence rates. In this study, decontamination with octenidine-based leave-on products was safe and effective in a critical patient population.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Anti-Bacterial Agents - therapeutic use
- Austria - epidemiology
- Bacterial Proteins - biosynthesis
- Bacterial Proteins - genetics
- Carrier State - microbiology
- Cohort Studies -
- Disinfection - methods
- Female -
- Humans -
- Male -
- Methicillin-Resistant Staphylococcus aureus - drug effects
- Middle Aged -
- Nasal Cavity - microbiology
- Penicillin-Binding Proteins - biosynthesis
- Penicillin-Binding Proteins - genetics
- Pyridines - therapeutic use
- Skin - microbiology
- Staphylococcal Infections - diagnosis
- Staphylococcal Infections - drug therapy
- Staphylococcal Infections - epidemiology
- Tertiary Care Centers -
- Trachea - microbiology
- Urinary Catheters - microbiology
- Find related publications in this database (Keywords)
- MRSA
- Prevalence
- Decontamination
- Octenidine
- Antiseptic
- Non-antibiotic